Education

• B.S. Biology, Fort Lewis College, Durango, Colorado, 1980
• B.S. Chemistry, Fort Lewis College, Durango, Colorado, 1982
• Ph.D., University of California, Irvine, 1989

Research Interests

• Neurotrophic interactions in the brain during development and regeneration
• Axon growth, targeting and sensory mapping
• Adult neural stem cells, neurogenesis and neuronal survival.
• Plasticity of sensory systems in response to brain injury, with a focus on the olfactory forebrain.

Professional Background

• University of California, Irvine/Research Assistant Professor, 1990-2001

Representative Peer Review Publications

• Ardiles Y, de la Puente R, Toledo R, Isgor C, Guthrie, K. Response of olfactory axons to loss of synaptic targets in the adult mouse. Exp Neurol., 207:275-288. 2007.
• Robertson R, J. Baratta, J. Wu and K.M. Guthrie. A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Neuroscience, . 1;143(2):523-39. 2006.
• Guthrie, K.M., A. Tran, J. Barrata and R. Robertson. Patterns of afferent projections to the dentate gyrus studied in organotypic co-cultures. Dev. Brain Research, 157: 162-171. 2005.
• Guthrie, K.M. and C.M. Gall. Anatomical mapping of neuronal odor responses in the developing rat olfactory bulb. J. Comp. Neurol. 455: 56-71.2003
• Guthrie, K.M., J. Rayhanabad and C. Gall. Odor regulation of Arc expression in neuronal ensembles engaged in odor coding. NeuroReport, 11: 1809-1813. 2000.
• Woods, A.G., K.M. Guthrie, M. Kurwala and C. Gall. Neurotrophic responses during sprouting are attenuated in the aged rat hippocampus. Neurosci. 83: 663-668. 1998.
• Gall, C.M., J.C Lauterbom, K.M. Guthrie and C.T. Stinis. Seizures and the regulation of neurotrophic factor expression: Associations with structural plasticity in epilepsy. In: Neuronal Regeneration. Reorganization and Repair, Advances in Neurology, vol. 59, F.I. Seil, Ed., Raven Press, N.Y., pp. 9-24. 1997.
• Guthrie, K.M., A.G. Woods, T. Nguyen and C. Gall. Astroglial CNTF expression is increased in fields of axonal sprouting in deafferented hippocampus. J. Comp. Neurol. 386: 137-148. 1997.
• Wilson, D.A., R. Sullivan, C.M. Gall, and K.M. Guthrie. NMDA receptor modulation of lateral inhibition and c-fos expression in olfactory bulb. Brain Res. 719: 62- 71. 1996.
• Gall, C.M., K.M. Guthrie and I.C. Lauterborn. Stimulation of neurotrophic factor expression: Links to different forms of brain plasticity. In: Life and Death in the Nervous System, C.F. Ibanez, K. Fuxe, T. Hokfelt, H. Iornvall, L. Olson and D. Ottodon, Eds., Pergamon Press, NY, pp. 275-296. 1995.
• Gall. C., I. Lauterborn and K. Guthrie. In situ hybridization: A sensitive measure of activity dependent changes in neuronal gene expression. In: Autoradiograhy and Correlative Imaging, W .E. Stumpf and H.F. Solomon, eds., Academic Press, N.Y., pp. 379-399. 1995.
• Guthrie, K.M. and C.M. Gall. Odor increases Fos in olfactory bulb neurons including dopaminergic cells. NeuroReport. 6:2145-2149. 1995.
• Guthrie, K.M., I.M. Holmes and M. Leon. Focal 2-DG uptake persists following olfactory bulb lesions. Brain Res. Bull. 38: 129-134. 1995.
• Guthrie. K.M., T. Nguyen and C.M. Gall. Insulin-like growth factor-1 mRNA is increased in deafferented hippocampus: Spatiotemporal coaespondence of a trophic event with axon sprouting. J. Comp. Neurol. 352:147-160. 1995.
• Guthrie, K.M. and C.M. Gall. Functional mapping of odor-activated neurons in the olfactory bulb. Chem. Senses, 20:271-282. 1995.