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College of Biomedical Science
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Department of Basic Science
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Haung, Xupei
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- M.D., Nanjing Medical University, Nanjing, China, 1985
- Ph.D., Biochemistry, University of Paris XII, France, 1992
- Intracellular signal pathways, protein phosphorylation and cellular function
- Gene expression profiling and gene regulation in the heart
- Functional evaluation of cardiac genes
- Transgenic and gene knockout animal models
- Texas A&M; University/Research Assistant Professor, 1996-2001.
- Huang, X.P., Walker, J.W. Myofilament anchoring of protein kinase C- in cardiac myocytes. J. Cell Science 117:1971-1978, 2004
- Jia, Y., Akerman, S., Huang, X.P. Disturbance of energy metabolism in cTnI gene knockout mouse hearts. J. Biomed Science 11:450-456, 2004
- Riedel B, Jia Y, Du J, Akerman S, Huang XP. Thyroid hormone inhibits slow skeletal TnI expression in cardiac TnI-null myocardial cells. Tissue & Cell 2004. (in press).
- Huang, X.P. and Du J. Troponin I and restrictive cardiomyopathy. Acta Pharmacol Sin. 25:1569-1575, 2004.
- Zhang C., Meng F., Huang XP, Lemanski SL, Foster D, Erginel-Unaltuna E, Dube DK, Lemanski FL. Downregulation of N1 gene expression inhibits the initial heartbeating and heart development inaxolotls. Tissue & Cell 36:71-81, 2004.
- Huang, X.P. and Walker JW. Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes. J. Cell Science 117: 1971-1978, 2004.
- Meng F, Huang XP, Foster D, Dawson N, Lemanski SL, Zawieja D, Lemanski LF. Cardiac protein tyrosine phosphorylation during axolotl embryo development. Tissue & Cell, 35: 133-142, 2003.
- Zhang, C., Dube, D.K., Huang, X.P., Zajdel RW, Lemanski SL, Meng F, Foster D, Lemanski LF. A Point Mutation in Bioactive RNA Results in RNA Secondary Structure Alteration and Failure of Mutant Heart Correction in Mexican Axolotls. Anat Embryol. 206: 495-506, 2003.
- Zhang, C., LaFrance, S.M., Lemanski, S.L., Huang, X.P., Dube D, Lemanski LF. Sheep heart RNA stimulates myofibril formation and beating in cardiac mutant axolotl hearts in organ culture. Anat Embryol. 206: 419-427, 2003.
- Huang, X.P., Li, J., Foster, D., Lemanski, S.L., Zhang, C., Lemanski, L.F. Protein kinase C mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart. Exp Biol Med. 227:1039-1046, 2002.
- Lemanski LF, Meng F, Lemanski SL, Dawson N, Zhang C, Foster D, Li Q, Nakatsugawa M, Dube DK, Huang XP. Creation of chimeric mutant axolotls: a model to study early embryonic heart development in Mexican axolotls. Anatomy and Embryology, 203:335-342, 2001.
- Huang XP, Lee K, Riedel B, Zhang C, Lemanski LF, Walker JW. Thyroid ormone regulates ssTnI inactivation in cTnI deficient mouse hearts. J Mol Cell Cardiol. 32: 2221-2228, 2000.
- Huang, X.P., Pi YQ, Lee KJ, Henkel AS, Gregg RG, Powers PA, Walker JW. Cardiac troponin I gene knockout: A mouse model of myocardial troponin I depletion. Circ Res. 84(1):1-8, 1999.
- Patel, J.R., Diffee, G.M., Huang, X.P., Moss RL. Phosphorylation of myosin regulatory light chain eliminates force-dependent changes in relaxation rates in skeletal muscle. Biophys J. 74:360-368, 1998.
- Huang, X.P., Pi, Y.Q., Lokuta AL, Greaser ML, Walker JW. Arachidonic acid stimulates protein kinase C- redistribution in heart cells. J. Cell Science 110:1625-1634, 1997.
- Hemlin, M., Huang, X.P. Na+/glucose cotransport in the colonic adenocarcinoma cell line HT29 cl.19A: effect of cAMP. Acta Physiol Scand 160:185-194, 1997.
- Pi, Y.Q., Sreekumar, R., Huang, X.P.., Walker JW. Positive inotropic mediated by the diacylglycerol/protein kinase C signaling pathway in rat ventricular myocytes. Circ Res 81:92-100, 1997.
- Sreekumar, R., Pi, Y.Q., Huang, X.P., Walker JW. Photolabile diacylglycerol precursors. Novel probes of cellular protein kinase C. Bioorg Med Chem Lett 3:341-346, 1997.
- Xia, J., Huang, X.P., Sreekumar R, Walker JW. Photolabile “caged” fatty acids containing a 1-(2’-nitrophenyl)-1, 2-ethanediol moiety. Bioorg Med Chem Lett 7:1243-1248, 1997.
- Huang, X.P., Sreekumar R, Patel JR, Walker JW. Response of cardiac myocytes to a ramp increase of diacylglycerol generated by photolysis of a novel caged diacylglycerol. Biophys J. 70:2448-2457, 1996.
- Huang, X.P., Heyman M, Nath SK, Castagna M, Desjeux JF. Distinct signaling mediates chloride secretion induced by tumor promoter bile salts and phorbol esters in human colonic cells. Int J Oncology. 6:1159-1163, 1995
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