Education

• M.D., Nanjing Medical University, Nanjing, China, 1985
• Ph.D., Biochemistry, University of Paris XII, France, 1992

Research Interests

• Intracellular signal pathways, protein phosphorylation and cellular function
• Gene expression profiling and gene regulation in the heart
• Functional evaluation of cardiac genes
• Transgenic and gene knockout animal models

Professional Background

• Texas A&M; University/Research Assistant Professor, 1996-2001.

Representative Peer Review Publications

• Du J., J. Liu, H.Z. Feng, M.M. Houssain, N. Gobara, C. Zhang, Y. Li, P.Y. Jean-Charles, J.P. Jin, X.P. Huang. Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI. Am. J Physiol Heart Circ Physiol. 294: H2604-H2613, 2008.
• Huang Q.Q., H.Z. Feng, J. Liu, J. Du, L.B. Stull, C.S. Moravec, X.P. Huang, J.P. Jin. Co-expression of skeletal and cardiac troponin T decreases mouse cardiac function. Am J Physiol Cell Physiol. 294:C213-C222, 2008.
• Du J., C. Nan, J. Huang, C. Zhang, J. Liu, P. Jia, X.P. Huang. Functional characterization of the promoters of mouse ssTnI in myocardial cells. J Biomed Sci. 15:605-613, 2008.
• Liu J., J. Du, C. Zhang, J.W. Walker, X.P. Huang. Progressive troponin I loss impairs cardiac relaxation and causes heart failure in mice. Am. J Physiol Heart Circ Physiol. 293:H1273-H1281, 2007.
• Du J., C. Zhang, J. Liu, C. Sidky, X.P. Huang. A point mutation (R192H) in the C-terminus of human cardiac troponin I causes diastolic dysfunction in transgenic mice. Arch. Biochem. Biophys. 456:143-150, 2006.
• Huang, X.P., Walker, J.W. Myofilament anchoring of protein kinase C- in cardiac myocytes. J. Cell Science 117:1971-1978, 2004
• Jia, Y., Akerman, S., Huang, X.P. Disturbance of energy metabolism in cTnI gene knockout mouse hearts. J. Biomed Science 11:450-456, 2004
• Riedel B, Jia Y, Du J, Akerman S, Huang XP. Thyroid hormone inhibits slow skeletal TnI expression in cardiac TnI-null myocardial cells. Tissue & Cell 2004. (in press).
• Huang, X.P. and Du J. Troponin I and restrictive cardiomyopathy. Acta Pharmacol Sin. 25:1569-1575, 2004.
• Zhang C., Meng F., Huang XP, Lemanski SL, Foster D, Erginel-Unaltuna E, Dube DK, Lemanski FL. Downregulation of N1 gene expression inhibits the initial heartbeating and heart development inaxolotls. Tissue & Cell 36:71-81, 2004.
• Huang, X.P. and Walker JW. Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes. J. Cell Science 117: 1971-1978, 2004.
• Meng F, Huang XP, Foster D, Dawson N, Lemanski SL, Zawieja D, Lemanski LF. Cardiac protein tyrosine phosphorylation during axolotl embryo development. Tissue & Cell, 35: 133-142, 2003.
• Zhang, C., Dube, D.K., Huang, X.P., Zajdel RW, Lemanski SL, Meng F, Foster D, Lemanski LF. A Point Mutation in Bioactive RNA Results in RNA Secondary Structure Alteration and Failure of Mutant Heart Correction in Mexican Axolotls. Anat Embryol. 206: 495-506, 2003.
• Zhang, C., LaFrance, S.M., Lemanski, S.L., Huang, X.P., Dube D, Lemanski LF. Sheep heart RNA stimulates myofibril formation and beating in cardiac mutant axolotl hearts in organ culture. Anat Embryol. 206: 419-427, 2003.
• Huang, X.P., Li, J., Foster, D., Lemanski, S.L., Zhang, C., Lemanski, L.F. Protein kinase C mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart. Exp Biol Med. 227:1039-1046, 2002.
• Lemanski LF, Meng F, Lemanski SL, Dawson N, Zhang C, Foster D, Li Q, Nakatsugawa M, Dube DK, Huang XP. Creation of chimeric mutant axolotls: a model to study early embryonic heart development in Mexican axolotls. Anatomy and Embryology, 203:335-342, 2001.
• Huang XP, Lee K, Riedel B, Zhang C, Lemanski LF, Walker JW. Thyroid ormone regulates ssTnI inactivation in cTnI deficient mouse hearts. J Mol Cell Cardiol. 32: 2221-2228, 2000.
• Huang, X.P., Pi YQ, Lee KJ, Henkel AS, Gregg RG, Powers PA, Walker JW. Cardiac troponin I gene knockout: A mouse model of myocardial troponin I depletion. Circ Res. 84(1):1-8, 1999.
• Patel, J.R., Diffee, G.M., Huang, X.P., Moss RL. Phosphorylation of myosin regulatory light chain eliminates force-dependent changes in relaxation rates in skeletal muscle. Biophys J. 74:360-368, 1998.
• Huang, X.P., Pi, Y.Q., Lokuta AL, Greaser ML, Walker JW. Arachidonic acid stimulates protein kinase C- redistribution in heart cells. J. Cell Science 110:1625-1634, 1997.
• Hemlin, M., Huang, X.P. Na+/glucose cotransport in the colonic adenocarcinoma cell line HT29 cl.19A: effect of cAMP. Acta Physiol Scand 160:185-194, 1997.
• Pi, Y.Q., Sreekumar, R., Huang, X.P.., Walker JW. Positive inotropic mediated by the diacylglycerol/protein kinase C signaling pathway in rat ventricular myocytes. Circ Res 81:92-100, 1997.
• Sreekumar, R., Pi, Y.Q., Huang, X.P., Walker JW. Photolabile diacylglycerol precursors. Novel probes of cellular protein kinase C. Bioorg Med Chem Lett 3:341-346, 1997.
• Xia, J., Huang, X.P., Sreekumar R, Walker JW. Photolabile “caged” fatty acids containing a 1-(2’-nitrophenyl)-1, 2-ethanediol moiety. Bioorg Med Chem Lett 7:1243-1248, 1997.
• Huang, X.P., Sreekumar R, Patel JR, Walker JW. Response of cardiac myocytes to a ramp increase of diacylglycerol generated by photolysis of a novel caged diacylglycerol. Biophys J. 70:2448-2457, 1996.
• Huang, X.P., Heyman M, Nath SK, Castagna M, Desjeux JF. Distinct signaling mediates chloride secretion induced by tumor promoter bile salts and phorbol esters in human colonic cells. Int J Oncology. 6:1159-1163, 1995