Education

• B.S., University 1982
• Ph.D., Molecular and Cellular Biology, University of Massachusetts, Amherst., 1988

Research Interests

• Hormone-regulated signal transduction
• Tumor metastasis
• Cell growth regulation

Professional Background

• Assistant Professor, Department of Surgery, Harvard Medical School, 1994-2006
• Instructor, Department of Surgery, Harvard Medical School, 1992-1994

Representative Peer Review Publications

• Wang H, McNight NC, Zhang T, Lu ML, Balk SP and Yuan X SOX9 is Expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells. Cancer Res. 2007; In Press
• Yuan X, Li T, Wang H, Zhang T, Barua M, Borgesi RA, Buble GJ, Lu ML and Balk SP Androgen receptor remains critical for cell cycle progression in androgen independent CWR22 prostate cancer cells. Am. J. Path. 2006; 169: 682-696
• Jia Z, Zhang A, Barbier L, Vadnais J, Noel J, Lu ML and. Nabi IR. Autocrine c- Met/HGF-R activation of localized Rho/ROCK/p38 MAP kinase signaling directs the protrusion of tumour cell pseudopodia. Biol. Cell 2006; 96:337-351
• Freeman MR, Cinar B and Lu ML. Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trens Endocrin. Metabol. 2005, 16:273-279
• Kaur R, Liu X, Gjoerup O, Zhang A, Balk SP, Yuan X, Schneider MC and Lu ML. Activation of p21 Activated Kinase (PAK6) by MAP kinase kinase 6 and p38 MAP kinase. J. Biol. Chem. 2005; 280:3323-3330.
• Mukhopadhyay NK, Gilchrist D, Gordon GJ, Chen C-J, Bueno R, Lu ML, Salgia R, Sugarbaker DJ, Jaklitsh MT. Integrin Dependent Protein Tyrosine Phosphorylation is a Key Regulatory Event in Collagen IV Mediated Adhesion and Proliferation of Human Ling Tumor Cell Line, Calu-1. Thor. Surgery 2004; 78:450-457.
• Wilbur A, O’Connor TP, Lu ML, Schneider MC. DNASE1L3 Deficiency in Lupusprone MRL and NZB/W F1 Mice. Clin Exp Immunol 2003; 134:46-52.
• Sukhova1 GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara1 Y, Chin MT, Libby P, Shi G-P. Deficiency of Cathepsin S Reduces Atherosclerosis In Low-Density Lipoprotein Receptor-Deficient Mice. J Clin Invest 2003; 111:897-906.
• Shi G-P, Sukhova GK, Kuzuya M, Zhang Y, Pan J-H, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee A M-E, Chapman HA, Libby P. Deficiency of The Cysteine Protease Cathepsin S Impairs Microvessel Growth. Circulation Res 2003; 92:493-500.
• Masiello D, Cheng S, Bubley G, Lu ML, Balk SP. Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. J Biol Chem 2002; 277:26321-6.
• Zhang Y, Fondell,JD, Xia X, Wang Q, Cheng A, Lu ML, Hamburger AW. Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1. Oncogene 2002; 21:5609-18.
• Wilbur A, Lu ML, Schneider MC. Media Containing DNASE1L3, and not DNASE1, confers a barrier to liposomal transfection. Mol Therapy 2002; 6:35-42.
• Zhuang L, Lin J, Lu ML, Solomon KR, Freeman MR. Cholesterol-rich lipid rafts mediate Akt-regulated cell survival in prostate cancer cells. Cancer Res. 2002; 62:2227- 31.
• Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML, Balk SP. Androgen and Estrogen Receptor Interaction with a Novel p21 Activated Kinase (PAK6). Mol Endocrin 2002; 16:85-99.
• Yuan X, Lu ML, Li T, Balk SP. SRY Interacts and Negatively Regulates Androgen Receptor Transactivational Activity. J Biol Chem 2001; 276:46647-54.
• Lu ML, Schneider MC, Zhang X, Richie JP. Caveolin-1 interacts with androgen receptor: a positive modulator of androgen receptor mediated transactivation. J Biol Chem 2001; 276:13442-51.

fellowships

• Hershey Fellow for Prostate Cancer Research, Hershey Foundation, 2002
• National Research Service Award, NIH, 1991-1992
• Neuromuscular Disease Research Fellow, Muscular Dystrophy Association1989-1990
• Postdoctoral Research Fellow, Dana-Farber Cancer Institute, 1988-1990