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Home / College of Biomedical Science / Faculty and Staff / Department of Basic Science / Prentice, Howard M. Dr.

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M.A. Honours, University of Aberdeen, 1980.
DEA. L'INSERM, Paris, France 1981.
M.Sc. University of London, England, 1984
Ph.D., University of London, England, 1987

Determination of regulatory characteristics of specific gene/promoter elements in normal and disease-stressed myocardial tissue with particular attention to the skeletal alpha actin and myosin heavy chain gene promoters and to hybrid hypoxia responsive/tissue specific promoters. Incorporation of hypoxia responsive promoters into regulated gene therapy vectors for ischaemia heart disease.
Characterisation of the effects of cardiac hypertrophy on the expression of the calcium regulatory molecules SERCA2a and phospholamban. Analysis of the role of phosphodiesterase type 4 isoenzymes and myotonic dystrophy protein kinase in regulating phospholamban phosphorilation status and in modifying cardiac myocyte adaptations to hypertrophy.
Examination of the effects on altered cardiac contractility of exoneous expression of contractile protein isoforms (troponin C fast, troponin T) in cardiac myocytes by means of adenoviral gene transfer into heart cells in culture and the myocardium in vivo.

Voluntary Associate Professor, Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL. 2002 - present
Associate Professor (Secondary Appointment) Department of Biological Sciences, Florida Atlantic University, Boca Raton, FL. 2002 - present
Associate Professor, Biomedical Sciences, Charles E. Schmidt College of Science, Florida Atlantic University, Boca Raton, FL. 2000 - present
University of Glasgow, Institute of Biomedical and Life Sciences, Glasgow, Scotland, Senior Lecturer with tenure, 1998 - 2000.
University of Glasgow, Division of Molecular Genetics and Department of Medicine and Therapeutics, Glasgow, Scotland, Senior Cardiovascular Fellow and Lecturer, 1993-1998.
University of Southern California, Department of Biochemistry and Institute for Genetic Medicine, Postdoctoral fellow, 1989 - 1993.
Stanford University School of Medicine, The MEDIGEN project (Molecular Genetics). Postdoctoral fellow, 1987 - 1989.

Jin, Y., Wu, H., Jin, H., Wei, J.N., Sha, D., Damania, H., Prentice, H., and Wu, J.Y. Mechanisms of genistein- and diadzein-induced neural toxicity. Journal of Neurobiology (in press).
Milton S. and Prentice, H: Beyond anoxia: The physiology of metabolic down-regulation and recovery in the anoxia-tolerant turtle. Comparative Biochemistry and Physiology (in press).
Milton SL., Nayak G., Kesaraju, S., Kara L. and Prentice, H: Suppression of reactive oxygen species production in the anoxia-tolerant turtle Trachemys scripta. J. Neurochem. (in press).
Milton, S., Nayak, G., Lutz, PL and Prentice, H: The regulation of neuroglobin gene transcription in hypoxia and anoxia in the brain of the anoxia-tolerant turtle Trachemys scripta. Journal of Biomedical Science 13, 509-514 (2006).
Prentice, H.M. and Webster KA. Proteomic analysis of heart function: Trends in Cardiovascular Medicine 14 (7) 282-288 (2004).
Prentice, H.M., Milton SL, Scheurle D, Lutz PL. The upregulation of cognate and inducible heat shock proteins in the anoxic turtle brain. J. Cerebral. Blood Flow and metabolism 24, 826-828 (2004).
Prentice, H.M., Milton SL, Scheurle D, Lutz PL. Voltage Gated Potassium Channel Gene Transcription Reversibly Regulated by Oxygen Supply. (American Journal of Physiology, Regul Integr Comp Physiol. Dec;285(6):R1317-21 (2003).
Lutz PL, Prentice, H.M., Milton SL. Is turtle longevity linked to enhanced mechanisms for surviving brain anoxia and reoxygenation (Experimental Gerontology 38, 797-800 (2003).
Webster, K.A., Kubasiak, L.A., Prentice, H. and Bishopric, N.H.: Stable germline transmission of a hypoxia-activated molecular gene switch.: in From the double helix to molecular medicine, (ed.W.J. Whelan et al.), Oxford University Press, (2003).
Dougherty, C., Hernandez, H., Prentice, H., Andreka, P., Bishopric, N.H., and Webster, KA. Activation of c-Jun N-terminal Kinase Promotes Survival of Redox stressed Cardiac Myocytes. Biochem. J. (362, 561-571 (2002).
Lutz, PL., Prentice, H. Sensing and responding to hypoxia, molecular and physiological mechanisms. Integrative and Comparative Biology 42: 436-468, 2002.
Webster KA, Prentice H, Bishopric NH.Oxidation of zinc finger transcription factors: physiological consequences. Antioxid Redox Signal. (2001) Aug;3(4):535-48.
Slapek, T.I., Webster, K.A., Zang, J., Prentice, H.M., O’Dowd, A., Hicks, M.N., Bishopric, N.H. Control of cardiac-specific transcription by p300 through myocyte enhancer factor 2-D. J. Biol. Chem. Nov 28 (2000).
Alexander, M.Y., Brosnan, M.J., Hamilton, C.A., Downie, P., Devlin, A.M., Dowell, F., Martin, W., Prentice, H.M., O’Brien, T., Dominiczak, A.F. Gene Transfer of endothelial nitric oxide synthase improves nitric oxide dependent endothelial function in a hypertensive rat model. Cardiovascular Research. Vol 43(3) (pp 798- 807), (1999).
Alexander, M.Y., Brosnan, M.j., Hamilton, C.A., Downie, P., Devlin, A.M., Dowell, F., Martin, W., Prentice, H.M., O'Brien, T., Dominiczak, A.F. Gene Transfer of endothelial nitric oxide synthase improves nitric oxide dependent endothelial function in a hypertensive rat model. Submitted 1999.
Morecroft, I., Heeley, R.P., Prentice, H., Kirk, A. and Maclean, M.R.: Expression and pharmacological characterisation of 5HT receptors in human small muscular pulmonary arteries: importance of the 5HT1 B receptor. Brit. J. Pharmacol., 128, 730-734 (1999).
Alexander, Y., Webster, K.A., McDonald, P. and Prentice, H.: Gene transfer and models of gene therapy for the myocardium. Clin. Exptl. Pharmacol. Physiol., 26,661-668 (1999).
Webster, K.A., Prentice, H., Discher, D.j., Hicks, M.C. and Bishopric, N.H.: Targetting and regulating the expression of foreign genes in ischemic tissues.: in Molecular biology in the conquest of disease, (ed.W.j. Whelan et al.), Oxford University Press, (1998).
Leor, j., Prentice, H., Sartorelli, V., Quinones, M.j., Patterson, M., Kedes, L.K. and Kloner, R.A.: Gene transfer and cell transplant: An experimental approach to repair a broken heart. Cardiovascular Research,35, 431-441(1997).
Prentice, H., Bishopric, N.H., Hicks, M.N., Discher, D.j., Wu, X., Wylie, A.A. and Webster, K.A.: Regulated expression of a foreign gene targeted to the ischaemic myocardium. in press -Cardiovascular Research -Focus on Gene Therapy Issue,567-574 (1997).
Prentice. H.M., Kloner, R.A., Newman, L., Li, Y., and Kedes, L;: Ischaemicl re perfused myocardium can express recombinant protein following direct DNA or retroviral injection. j. Mol. Cell. Cardiol.28, 133-140 (1996).
McDonald, P., Hicks, M.N., Cobbe, S.M. and Prentice, H.: Gene transfer in models of myocardial ischemia. Annals. New York Acad. Sci. 752, 455-459 (1995).
Prentice, H.M., Kloner, R.A., Newman, L., Li, Y., Christensen, T., Prigozy, E. and Kedes, L.: Tissue restricted expression patterns of two muscle specific promoters are retained with direct DNA injection assay into cardiac and skeletal muscle. J. Mol. Cell. Cardiol. 26, 1393-1401 (1994)

Nilsson and . The Brain without Oxygen: Kluwer Scientific . (2003).