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Department of Basic Science
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Shibata, Yoshimi Dr.
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- BS Yamagata University, Yamagata, Japan 1973
- Ph.D. Tohoku University School of Medicine, Bacteriology, Sendai, Japan 1982
- Ontogenic and functional heterogeneity of macrophage populations.
- Macrophage-mediated regulation of innate and acquired immune responses.
- Phagocytosis-mediated immunoregulations: Intracellular trafficking of particles and activation of cellular signaling.
- Development of a new Th1 adjuvant, beneficial against intracellular bacterial infections as well as childhood asthma.
- Mechanisms of Th1-to-Th2 shifts of immune responses in chronic inflammatory cardiovascular diseases.
- East Carolina University Brody School of Medicine, Greenville, NC. Research Associate Professor, 1996 - 2003.
- George Mason University, Medical Sciences Research Inst, Herndon, VA. Associate Scientist/Associate Professor, 1994-1996.
- East Carolina University School of Medicine, Dept. Pathology, Greenville, NC. Research Assistant Professor, 1989 - 1994.
- Hayashibara Biochemical Laboratories, Inc., Fujisaki Cell Center, Assistant to Director, Japan, 1987-1989
- Shibata Y, Nishiyama, A., Ohata, H., Gabbard, J., Myrvik, Q.N., Henriksen, R.A. Differential effects of IL-10 on prostaglandin H synthase-2 expression and prostaglandin E2 biosynthesis between spleen and bone marrow macrophages. J. Leuko. Biol. (in press).
- Van Scott, M.R., Hooker, J.L., Ehrmann, D.,Shibata, Y., Kukoly, C., Salleng, K., Westergaard, G., Sandrasagra, A., Nyce, J. Dust mite-induced asthma in Cynomolgus monkeys. J Appl Physiol 96:1433-1444, 2003. .
- Justice, J.P., Borchers, M.T., Lee, J.J., Rowan, W.H. Shibata, Y., Van Scott, M.R. Ragweed-induced expression of GATA-3, IL-4, and IL-5 by eosinophils in the lungs of allergic C57Bl/6 mice. Am J Physiol Lung Cell Mol Physiol 282:L302-309, 2002.
- Shibata, Y., Honda, I., Justice, J.P., Van Scott, M.R., Nakamura, R.M., Myrvik, Q.N. A Th-1 adjuvant --- N-acetyl-D-glucosamine polymer up-regulates Th-1 immunity but down-regulates Th-2 immunity against a mycobacterial protein (MPB-59) in interleukin-10-knockout and wild- type mice. Infect Immun 69:6123-6130, 2001.
- Justice, J.P., Shibata, Y., Sur, S., Mustafa, J., Fan, M., Van Scott, M.R. IL-10 gene knockout attenuates allergen-induced airway hyperresponsiveness in C57BL/6 mice. Am J. Physiol Lung Cell Mol Physiol. 280:L363-368, 2001.
- Shibata, Y. , Foster, L.A., Bradfield, J.F., and Myrvik, Q. N. Oral administration of poly N- acetyl-D-glucosamine downregulates serum IgE levels and lung eosinophilia in the ragweed-sensitized allergic mouse. J. Immunol. 164:1314-1321, 2000.
- American Association of Immunologist
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