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Department of Clinical Science and Medical Education Faculty
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Schmidt-Kastner, Rainald. Dr.
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- M.D., University of Duesseldorf, Germany, 1984.
- Brain ischemia and hypoxia
- Gene expression
- Selective vulnerability of the brain
- Scientist, Dept. of Biological Sciences, FAU, 2005.
- Research Associate Professor, Dept. of Neurology, University of Miami School of Medicine, 2002-2004.
- Research Assistant Professor, Dept. of Neurology, University of Miami School of Medicine, 1997-2002.
- Visiting Scientist, Neuroscience Research Institute, University of Ottawa, Ottawa, Canada, 1994-1996.
- Visiting Scientist, Karolinska Institute, Depts. Clinical Neurophysiology, Histology-Neurobiology, and Neuroscience, Stockholm, Sweden, 1990-1994.
- Scientific Assistant (postdoctoral), Max-Planck-Institute for Neurological Research, Cologne, Germany, 1983-1987.
- Scientific Assistant (postdoctoral), Ruhr-University Bochum, Dept. Neurophysiology, Germany, 1987-1992.
- Schmidt-Kastner, R., van Os, J., Steinbusch, H.W.M., Schmitz, C. Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia. Schizophrenia Res. 84: 253-271, 2006.
- Yamamoto, H., Schmidt-Kastner, R., Hamasaki, D.I., Yamamoto, H., Parel, J.-M. Complex neurodegeneration in retina following moderate ischemia induced by bilateral common carotid artery occlusion in Wistar rats. Exp. Eye Res. 82:767-79, 2006.
- Schmidt-Kastner, R., Aguirre-Chen, C., Saul, I., Yick, L., Hamasaki, D., Busto, R., Ginsberg, M.D. Astrocytes react to moderate ischemia in the forebrain induced by chronic bilateral common carotid artery occlusion in rats. Brain Res. 1052: 28-39, 2005.
- Schmidt-Kastner, R., Aguirre-Chen, C., Kietzmann, T., Saul, I., Busto, R., Ginsberg, M.D. Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus. Brain Res. 1001: 133-142, 2004.
- Schmidt-Kastner, R., Zhang, B.T., Belayev, L., Khoutorova, L., Amin, R., Busto, R., Ginsberg, M. D. DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat. Mol. Brain Res. 108: 81-93, 2002.
- Schmidt-Kastner, R., Truettner, J., Zhao, W., Saul, I., Busto, R., Ginsberg, M.D. Transient changes of brain-derived neurotrophic factor (BDNF) mRNA expression in hippocampus during moderate ischemia induced by bilateral common carotid artery occlusions in the rat. Mol. Brain Res. 92: 157-166, 2001.
- Kietzmann, T., Knabe, W., Schmidt-Kastner, R. Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death. Eur. Arch. Psychiatry Clin. Neurosci. 251: 170-178, 2001.
- Schmidt-Kastner, R., Truettner, J., Zhao, W., Belayev, L., Krieger, C., Busto, R., Ginsberg, M.D.Differential changes of bax, caspase-3 and p21 mRNA expression after transient focal brain ischemia in the rat. Mol. Brain Res. 79: 88-101, 2000.
- Truettner, J., Schmidt-Kastner, R., Busto, R., Alonso, O.F., Loor, J.Y., Dietrich, W.D., Ginsberg, M.D. Expression of brain-derived neurotrophic factor, nerve growth factor and heat shock protein HSP70 following fluid-percussion brain injury in rats. J. Neurotrauma 16: 471-486, 1999.
- Schmidt-Kastner, R., Zhao, W., Truettner, J., Belayev, L., Busto, R., Ginsberg, MD. Pixel-based image analysis of HSP70, GADD45 and MAP2 mRNA expression after focal cerebral ischemia: hemodynamic and histological correlates. Mol. Brain Res. 63: 79-97, 1998.
- Matsushima, K., Schmidt-Kastner, R., Hogan, M.J., Hakim, A.M.Cortical spreading depression activates trophic factor expression in neurons and astrocytes and protects against subsequent focal brain ischemia. Brain Res. 807: 47-60, 1998.
- Schmidt-Kastner, R., Fliss, H., Hakim, A.M. Subtle neuronal death in striatum after short forebrain ischemia in rat detected by in situ end-labelling for DNA damage. Stroke 28: 163-170, 1997.
- Schmidt-Kastner, R., Bedard, A., Hakim, A. Transient expression of GAP-43 within hippocampus after transient global brain ischemia in rat. Cell Tissue Res. 228: 225-238, 1997.
- Schmidt-Kastner, R., Wetmore, C., Olson, L. Comparative study of brain-derived neurotrophic factor (BDNF) mRNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience 74: 161-183, 1996.
- Schmidt-Kastner, R., Humpel, C., Wetmore, C. , Olson, L. Changes of BDNF-, trkB-, and NGF-mRNA and BDNF-like immunoreactivity in hippocampus and cortex after status epilepticus induced by pilocarpine in rats. Exp. Brain Res. 107: 331-347, 1996.
- Schmidt-Kastner, R., Tomac, A., Hoffer, B., Bektesh, S., Rosenzweig, B., Olson, L. Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats. Mol. Brain Res. 26: 325-330, 1994.
- Schmidt-Kastner, R., Ingvar, M. Loss of immunoreactivity for glial fibrillary acidic protein (GFAP) in astrocytes as marker for profound tissue damage in substantia nigra and basal cortical areas after status epilepticus induced by pilocarpine in rat. Glia 12: 165-172, 1994.
- Schmidt-Kastner, R., and Eysel, U. Ischemic damage visualized by flat-mounts of rat retina after photochemically-induced thrombosis. Brain Res Bull. 34: 487-491, 1994.
- Schmidt-Kastner, R., Wietasch, K., Weigel, H., Eysel, U.-T. Immunohistochemical staining for glial fibrillary acidic protein (GFAP) after deafferentation or ischemic infarction in rat visual system: features of reactive and damaged astrocytes. Int. J. Dev. Neurosci. 11: 157-174, 1993.
- Schmidt-Kastner, R., Meller, D., Eysel, U.T. Immunohistochemical changes of neuronal calcium-binding proteins parvalbumin and calbindin-D28k following unilateral deafferentation in the rat visual system. Exp. Neurol. 117: 230-246, 1992.
- Schmidt-Kastner, R., Freund, T.F. Selective vulnerability of the hippocampus in brain ischemia. Commentary. Neuroscience 40: 599-636, 1991.
- Schmidt-Kastner, R., Szymas, J., Hossmann, K.-A. Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia. Neuroscience 38:527-540, 1990.
- Schmidt-Kastner, R., Paschen, W., Grosse Ophoff, B., Hossmann, K.-A. A modified four-vessel occlusion model for inducing incomplete forebrain ischemia in rat. Stroke 20: 938-946, 1989.
- Schmidt-Kastner, R., Hossmann, K.-A. Distribution of ischemic cell change in the dorsal hippocampus of rat. Acta Neuropathol. 76: 411-421, 1988.
- Schmidt-Kastner, R., Hossmann, K.-A., Grosse Ophoff, B. Pial artery pressure after one hour of global ischemia. J. Cereb. Blood Flow Metabol. 7: 109-117, 1987.
- Mai, J.K., Schmidt-Kastner, R., Tefett, H.-B. Use of acridine orange (AO) for histological analysis of the central nervous system. J.Histochem.Cytochem. 32: 97-104, 1984.
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