Dr. Janet D. Robishaw’s research focuses on G-protein coupled receptor signaling pathways that represent targets for more than 60% of all biomedical drugs on the market. Particularly abundant in the brain, GPCR signaling pathways must integrate many cellular functions to produce a coordinated neurological response.
Dr. Robishaw’s team explores the action of these proteins and receptors from molecular, cellular, and developmental standpoints. They’ve explored the G-protein coupled signaling roles in neurologic and psychiatric diseases. In addition, they have applied this information to create humanized, mouse models of disease that can be used to explore the defective mechanisms underlying diseases and to test new investigational drugs. This comprehensive approach has provided the first conclusive evidence that the gamma subtypes are major determinants of signaling specificity, paving the way for the design of more selective drugs to treat a range of neurologic and psychiatric disorders.
1979: B.S., Chemistry and biology, Central Michigan University, Mt. Pleasant, MI
1983: Ph.D. Cellular and Molecular Biology, Pennsylvania State University, College of Medicine, Hershey, PA
2017-Present: Interim Dean for Research, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL
2016-Present: Chair of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL
2016-Present: Professor of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL
2005-2016: Associate Director, Geisinger Health System, Weis Center for Research, Danville, PA
2004-2016: President and CEO, SignalPlex, Danville, PA
2000-2016: Senior Scientist, Geisinger health System, Weis Center for Research, Danville, PA
2000-2016: Director of Research Education, Geisinger Clinic, Weis Center for research, Danville PA
1997-2000: Professor with tenure, Department of Molecular and Cellular Physiology, Pennsylvania State University, Hershey, PA
1996-1997: Senior Scientist, Geisinger Health Clinic, Weis Center for Research, Danville, PA
1987-1996: Staff Scientist, Geisinger Health Clinic, Weis Center for Research, Danville, PA
1983-1987: Post-doctoral Fellow and Research Assistant Professor Supervisor, Dr. Alfred G. Gilman, Nobel Laureate (1994 Nobel Prize in Physiology and Medicine) University of Texas Health Sciences Center, Southwestern Medical School Dallas, TX
Schwindinger WF, Sheridan K, Boscarino J, Erlich P, Gerhard G, and Robishaw JD. The G-protein γ7 is a likely genetic contributor to opioid actions in humans and mice, In preparation.
Chen H, Leung TC, Humbert J, Stauffer A, Sinha S, Giger K, Hansen CA, and Robishaw JD. Critical role for the zebrafish G protein γT1 subunit in melatonin production, In preparation.
Mi W, Lin Q, Childress C, Sudol M, Robishaw J, Berlot CH, Shabahang M, Yang W. Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration. Oncogene. 2014 Aug 11. doi: 10.1038/onc.2014.251. [Epub ahead of print]
Moon AM, Stauffer AM, Schwindinger WF, Sheridan K, Firment A, Robishaw JD. Disruption of G-protein γ5 PLoS One, 9(3): e90970, 2014. subtype causes embryonic lethality in mice.
Robishaw JD. Preferential assembly of G-proteins by the γ subunits. Subcell Biochem. 63: 181-91, 2012.
Schwindinger WF, Mirsahi U, Baylor KA, Sheridan KM, Stauffer AM, Usefof S, Stecker MM, Mirshahi T, Robishaw JD. Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knockout mice. J Biol. Chem. 287(10):7121-33, 2012.
1983-1986 National Research Service Award, National Institute of Health
1988 Selected Speaker, Science Writer's Forum, American Heart Association
1988-89 Regular Member of Biochemistry Study Section, National American Cancer Society
1989 Member of Research Review Group, Pennsylvania Affiliate of the American Heart Association
1990 Member of SCOR Review Committee, National Institutes of Health
1989-1994 Established Investigator Award, National American Heart Association
1990 Delegate for National Institutes of Health US-USSR Symposium on “Cardiovascular and Pulmonary Biology”, Suzdal, USSR
1991-1995 Regular Member of Pharmacology Study Section, National Institutes of Health
1993 Advisory Panel Member, “Future Directions in Neuroscience Research”, National Institutes of Health
1993-1998 Editorial Board Member, Journal of Biological Chemistry
1996 Chairperson for ASPET Symposium on "Role of βγ subunits in G protein- mediated signaling”, Experimental Biology '96 Meeting.
1996-2000 Regular Member and Co-Chair of the Molecular Signaling I Study Section, National American Heart Association
1999-2002 Regular Member, Pharmacology Study Section, National Institutes of Health 2002-2005 Executive Committee Member, Cardiovascular Division, American Society of Pharmacology and Therapeutics
2009 Reviewer, Glue Grant, National Institutes of Health
2007-2012 Regular Member of Molecular and Integrative Signal Transduction, National Institutes of Health
2013 Ad hoc Member, Vascular Biology, National Institutes of Health