Keith Brew, Ph.D., is a Professor of Biomedical Science. Besides his responsibilities associated with for the administration of his department, Dr. Brew teaches in the graduate and medical education programs of the College of Medicine and has research interests involving the development of novel treatments for osteoarthritis and other diseases using engineered protein inhibitors and enzymes involved in the synthesis of complex carbohydrate structures attached to cell surfaces and extracellular proteins, whose activities affect interactions between the immune system and pathogenic bacteria and viruses.
- 1962: B.Sc. (Hons), Biochemistry, University College London, London, U.K.
- 1966: Ph.D., University of London, Courtauld Inst. of Biochemistry, London, U.K.
- 1966-1968: Postdoctoral Fellow, Duke University, Durham, North Carolina
- 2007-Present: Chair, Department of Biomedical Science, Charles E, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida
- 2001-Present: Professor of Biomedical Science, Florida Atlantic University, Boca Raton, Florida
- 2001-2016: Schmidt Senior Fellow, Florida Atlantic University, Boca Raton, Florida
- 2001-Present: Emeritus Professor, Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida
- 1977-2001: Professor, Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida
- 1991-1995: Interim Co-Chair, Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida
- 1989-1991: Vice-Chairman, Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida
- 1974-1977: Associate Professor of Biochemistry, University of Miami, Miami, Florida
- 1972: (July-September), Visiting Research Fellow, Department of Biochemistry, Duke University Medical Center, Durham, North Carolina
- 1968-1974: Lecturer, Department of Biochemistry, University of Leeds, U.K.
Brew, K. and Lizotte-Waniewski, M (2015) Naturally-Occurring Polypeptide Inhibitors: Cystatins/Stefins, Inhibitors of Apoptosis (IAPs),Serpins, and Tissue Inhibitors of Metalloproteinases (TIMPs), in “Encyclopedia of Cell Biology” edited by RA Bradshaw and PD Stahl, Academic Press, in press
- Pham, T.T.K., Stinson, B., Thiyagarajan, N., Lizotte-Waniewski, M., Brew, K., and Acharya, K.R. (2014) Structures of Complexes of a Metal-independent GT6 from Bacteroides ovatus with UDP-GalNAc and its Hydrolysis Products. J. Biol. Chem. 289, 8041-8050.
- Thiyagarajan, N., Pham, TTK. Stinson, B., Sundriyal, A., Tumbale, P., Lizotte-Waniewski, M., Brew, K., and Acharya, K.R. (2012) Molecular structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen. Scientific Reports, 2: 940
- Ashutosh, C.C., Borgmann, K., Brew, K. and Ghorpade, A. (2012) Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: Mechanisms and relevance to HIV-1-associated dementia. Cell Death & Disease 3, e332
Brew, K. (2011) Milk Proteins: _-Lactalbumin. In “Encyclopedia of Dairy Sciences 2nd Edition” Fuquay, JW Fox, PF and McSweeney, PLH (eds) 3, pp 780-786.
- Bahudhanapati, H., Zhang, Y., Sidhu, S.S., and Brew, K. (2011) Phage display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2): Identification of selective inhibitors of Collagenase-1 (MMP-1). J. Biol. Chem. 286, 31761-31770.
Brew, K., and Page-McCaw, A. (2011) Dm1 and Dm2 matrix metalloproteinases. in “Handbook of Proteolytic Enzymes”, 3rd edition (Ed. by Rawlings, N.D. and Salveson, G.
- Wu, Y., Wei, S., Van Doren, S.R., and Brew, K. (2011) Entropy increases from different sources support the high-affinity binding of the N-terminal inhibitory domains of tissue inhibitors of metalloproteinases (N-TIMPs) to the catalytic domains of matrix metalloproteinases (MMPs) -1 and-3. J. Biol. Chem. 286, 16891-16899.
Brew, K., Tumbale, P., and Acharya, K.R. (2010) Family 6 Glycosyltransferases in Vertebrates and Bacteria: Inactivation and Horizontal Gene Transfer May Enhance Mutualism between Vertebrates and Bacteria. J. Biol. Chem. 258, 37121-37127.
- Lim, N.H., Kashiwagi, M., Visse, R.,Jones, J., Jan J. Enghild, J.J., Brew, K. and Nagase, H. (2010) Reactive site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: Biological and structural implications. Biochem. J. 431, 113-122.
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- Structural and biophysical origins of specificity in protein-protein interactions
- Engineering protein inhibitors of metalloproteinases to enhance specificity
- Structural basis of specificity and catalysis in glycosyltransferases.
- Evolutionary relationship between vertebrate and bacterial glycosyltransferases that produce histo-blood group antigens