Marc Kantorow, Ph.D.'s laboratory focuses on understanding mitochondrial mechanisms in ocular development and disease. Specifically his group focuses on the eye lens and the retina as models for understanding cell differentiation, cell function and disease. His group's work ranges from analysis of the functions of genes identified to cause ocular disease when mutated, to the direct of effects of UV-light and other agents associated with the development of ocular disease on mitochondrial and other cell functions. In addition to understanding the how the functions of ocular cells are altered in disease states, his group also examines how manipulation of key cell systems can be applied to treat and/or prevent ocular diseases including age-related cataract formation and macular degenerations that are the leading causes of visual disability.
Finally, his group is using the knowledge gained from these studies to engineer cell systems and cells that can be transplanted into cells or tissues to restore the functions of damaged organs. A wide variety of techniques are employed by Dr. Kantorow's group including human genetic analysis, protein biochemistry, cell biology, molecular biology, gene expression studies, confocal and electron microscopy, transgenic and knockout mouse and chick models, Bioinformatic analysis, computational biology and global expression and gene modification analysis. Dr. Kantorow's laboratory and research program have been continually funded by the National Eye Institute, National Institutes of Health for the last 18 years. His work has also been supported by the American Health Assistance Foundation and the Rand Eye Institute of Boca Raton.
- 1985: B.S., (Cum Laude), Biology, Towson State University, Towson, MD
- 1991: Ph.D., Genetics, George Washington University, Washington, D.C.
- 2016-Present: Assistant Dean of Graduate Programs, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida
- 2013-2016: Director of Graduate Programs, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida
- 2007-Present: Professor (tenured,) Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida
- 2003-2007: Associate Professor, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida
- 2004-2006: Associate Chair, Department of Biomedical Science, Florida Atlantic University, Boca Raton, Florida
- 1999-2003: Assistant Professor, Department of Biology, West Virginia University, Morgantown, West Virginia
- 1997-1999: Assistant Research Professor, The Jules Stein Eye Institute, UCLA Medical School, Los Angeles, California
- 1996-1997: Senior Staff Fellow, National Eye Institute, NIH, Bethesda, MD
- Parkin elimination of mitochondria is important for maintenance of lens cell ROS levels and survival upon oxidative stress exposure. Biochimica Biophysica Acta (BBA) Molecular Basis of Disease. in revision.
- Identification and ultrastructural characterization of a novel nuclear degradation complex in differentiating lens fiber cells. M. Joseph Costello, Lisa A. Brennan, Kurt O. Gillaland, Snoke Johnson, Marc Kantorow. PloS One. in press.
- Chromatin remodeling enzyme Snf2h/Smarca5 regulates embryonic lens differentiation and denucleation. Shuying He, Saima Limi, Rebecca S. McGreal, Qing Xie, Lisa Ann Brennan, Wanda Kantorow, Juraj Kokavec, Romit Majumdar, Harry Hou, Winfried Edelmann, Wei Liu, Ruth Ashery-Padan, Jiri Zavadil, Marc Kantorow, Arthur Skoultchi, Tomas Stopka, Ales Cvekl. Development. 2016. 143(11):1937-47.
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky et al., Autophagy. 2016. 12(1):1-222.
- Integrin αVβ5-mediated Removal of Apoptotic Cell Debris by the Eye Lens and Its Inhibition by UV Light Exposure. Dan Chauss, Lisa Brennan, Olga Bakina and Marc Kantorow. J Biol Chem. 2015. 290(51):30253-66.
- Integrin αVβ5-mediated Phagocytosis by Eye Lens Epithelial Cells Enhances Cell Viability Under Apoptotic Conditions Brennan LA, Chauss D, Kantorow M. Journal of Biological Chemistry. In revision.
- Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. Chauss D, Basu S, Rajakaruna S, Ma Z, Gau V, Anastas S, Brennan LA, Hejtmancik JF, Menko AS, Kantorow
M. G3 (Bethesda). 2014 Jun 13. pii: g3.114.012120
- Autophagy and mitophagy participate in ocular lens organelle degradation.Costello MJ, Brennan LA, Basu S, Chauss D, Mohamed A, Gilliland KO, Johnsen S, Menko AS, Kantorow M. Exp Eye Res. 2013 Nov;116:141-50.
Chaperone-independent mitochondrial translocation and protection by αB-crystallin in RPE cells. McGreal RS, Brennan LA, Kantorow WL, Wilcox JD, Wei J, Chauss D, Kantorow M. Experimental Eye Research 2013 May;110:10-7. doi: 10.1016/j.exer.2013.02.016. Epub 2013 Mar 4.
- Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells. Brennan LA, Kantorow WL, Chauss D, McGreal R, He S, Mattucci L, Wei J, Riazuddin SA, Cvekl A, Hejtmancik JF, Kantorow M. Molecular Vision. 2012;18:1773-86. Epub 2012 Jun 30.
- αB-crystallin/sHSP protects cytochrome c and mitochondrial function against oxidative stress in lens and retinal cells. McGreal RS, Kantorow WL, Chauss DC, Wei J, Brennan LA, Kantorow M. Biochimica Et. Biophysica Acta. 2012 Jul;1820(7):921-30. doi: 10.1016/j.bbagen.2012.04.004. Epub 2012 Apr 12.
- Mutations in FYCO1 cause autosomal-recessive congenital cataracts. Chen J, Ma Z, Jiao X, Fariss R, Kantorow WL, Kantorow M, Pras E, Frydman M, Pras E, Riazuddin S, Riazuddin SA, Hejtmancik JF. American Journal of Human Genetics. 2011 Jun 10;88(6):827-38. doi: 10.1016/j.ajhg.2011.05.008.
TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens. Brennan LA, Lee W, Kantorow M. PLoS One. 2010 Nov 4;5(11):e15421. doi: 10.1371/journal.pone.0015421.
Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions. Yang C, Yang Y, Brennan L, Bouhassira EE, Kantorow M, Cvekl A. FASEB Journal. 2010 Sep;24(9):3274-83. doi: 10.1096/fj.10-157255. Epub 2010 Apr 21.
- Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon methionine oxidation. Brennan LA, Lee W, Giblin FJ, David LL, Kantorow M. Biochimica Et. Biophysica Acta. 2009 Dec;1790(12):1665-72. doi: 10.1016/j.bbagen.2009.08.011. Epub 2009 Sep 3.
Recent Invited Presentations
- 2015 The International Conference on Eye Research, Kona, Hawaii
- 2015 UCLA Medical school, Jules Stein Eye Institute, LA, CA
- 2014 Autophagy and the Eye Symposium, Association for Research in Vision and Ophthalmology, Orlando, FL
- 2014 Wills Eye Institute Annual Research Symposium, Jefferson University, Philladelphia, PA
- 2013 Annual Meeting of Cell Biology and Anatomy Chairs USA, Puerto Rico.
Recent Meeting and Symposia Organization
- 2008 Chair Young Investigator Program, International Conference on Eye Research, Bejing China
- 2010 Co-Chair Lens Program International Conference of Eye Research, Montreal, Canada
- 2012 Co-Chair Lens protective Mechanisms, International Conference of Eye research, Berlin, Germany
- 2013 Co-Chair Lens Organelle Mechanisms, Assoc. Vis. Ophthalmology, Denver, Co.
- 2015 Co-Chair Lens Differentiation Mechanisms, Assoc. Vis. Ophthalmology, Denver, Co.
- 2016 Co-Chair Cataract Mechanisms and Therapies, International Conference on Lens Research, Kona, Hawaii.
- Editorial Board Molecular Vision
NIH R01 2009-2014 $1,752,000.00 NIH RO1 EY 13022 (sole PI) National Eye Institute NIH “Molecular Analysis of Microdissected Human Lenses” at Florida Atlantic University
NIH NOT 2009-2010 $258,000 NOT OD 056 Recovery Act (sole PI) National Eye Institute NIH "Repair of alphacrystallin" at Florida Atlantic University
NIH R01 2004-2009 $1,561,590.00 NIH RO1 EY 13022 (sole PI) National Eye Institute NIH "Molecular Analysis of Microdissected Human Lenses" at Florida Atlantic University
AHAF 2005-2007 $100,000 American Health Assistance Foundation for Macular Degeneration (sole PI) “The role of methionine sulfoxide reductase in retinal function and age-related macular degeneration” at Florida Atlantic University
PHS 2006-2007 Palm Healthcare Foundation BJ Harris Fund for Macular Degeneration (sole PI) $15,000 at Florida Atlantic University
NIH R01 1999-2004 $966,220.00 NIH RO1 EY 13022 (sole PI) National Eye Institute NIH "Molecular Analysis of Microdissected Human Lenses" at West Virginia University
Recent Grant Review Committees
02/11/2013 at CSR
Meeting 2013/05 BVS Basic Visual Science Study Secrtion-ad hoc
05/28/2013 at CSR
Meeting 2013/10 ZRG1-BDCN-H-02 Visual Sciences -ad hoc
11/08/2013 at CSR
Meeting 2014/01 ZRG1-BDCN-H-02 Visual Diseases-ad hoc
03/18/2014 at CSR
Meeting 2014/05 ZRG1-BDCN-H-02-Visual Science-ad hoc
06/19/2014 at CSR
Meeting 2014/10 BVS Basic Visual Science Study section-ad hoc
11/05/2014 at CSR
Meeting 2015/01 ZRG1-BDCN-L-02 Visual Biology-AS CHAIR
Meeting Oct 2015 at CSR
Present member BVS Basic Visual Science Study section-ad hoc
Professional Memberships and Committees
- Present: Association of Research in Vision and Opthalmology (ARVO)
- Present: International Society of Eye Research (ISER)
- 2010-2013: Association Research in Vision and Ophthalmology Members in Training Committee
- 2007-2010: (2010 as Chair) Association Research in Vision and Ophthalmology Lens Program Committee
- 2015-Present: International Society for Eye Research Members in Training Committee
Awards and Fellowships
- 2016: Charles E. Schmitt College of Medicine Nominee for Florida Atlantic University Teacher of the Year
- 2015: Certificate of Appreciation for Service on the Association for Research and Visual Science Members in Training Committee (2011-2014)
- 2002: Cataract Research Award National Foundation For Eye Research
- 2012: Fellow of Association for Research in Vision and Ophthalmology Silver
- 2014: Fellow of Association for Research in Vision and Ophthalmology Gold