College of Medicine / About / Departments / Biomedical Science Department / Andrew Oleinikov, Ph.D.


       

Charles E. Schmidt College of Medicine
Florida Atlantic University
777 Glades Road
Boca Raton, FL 33431

561-297-4828

ANDREW OLEINIKOV, Ph.D.

Associate Professor of Biomedical Science


oleinikov
CONTACT
aoleinikov@health.fau.edu
Tel. (561) 297-4424

 
 

 

Andrew Oleinikov, Ph.D., is an associate professor of biomedical science. His research interests include functions of surface proteins of human parasite Plasmodium falciparum and mechanisms of parasite-host interactions, identification of malaria vaccine candidates, molecular mechanisms of low birth weight in placental malaria, and screening of drugs that specifically prevent adhesion of malaria parasitized erythrocytes to the host endothelial and immune cells. In addition, he works on development of tools and technologies for single cell analysis and high throughput approaches, as well as functional role of a giant endocytic and signaling receptor megalin in various tissues.

 

 

 

  • 1983: M.S. (hons) in Biophysics, St. Petersburg Polytechnical University, St. Petersburg, Russia
  • 1989: Ph.D. in Biology, Moscow State University, Moscow, Russia

  • 2013–Present: Associate Professor of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida
  • 2004-2013: Principal Scientist, Seattle Biomedical Research Institute, Seattle, WA
  • 2000-2003: Principal Scientist and Group Leader, CombiMatrix Corp., Mukilteo, WA
  • 1997-2000: Research Assistant Professor, Department of Pediatrics, School of Medicine, University of California, Davis
  • 1995-1996: Post-doctoral fellow, Department of Pediatrics, School of Medicine, University of California, Davis
  • 1991-1994: Post-doctoral fellow, Department of Biological Chemistry, School of Medicine, University of California, Davis 

 

  • Tcherniuk, S.O., & Oleinikov AV – Pgp efflux pump decreases the cytostatic effect of CENP-E inhibitor GSK923295. (2015) Cancer Letters, 361(1), 97-103.
  • Gullingsrud J, Milman N, Saveria T, Chesnokov O, Williamson K, Srivastava A, Gamain B, Duffy PE, Oleinikov AV – High throughput screening platform identifies small molecules that prevent sequestration of Plasmodium falciparum-infected erythrocytes. (2015) J. Infect. Diseases V. 211 (7), p. 1134–43
  • Gullingsrud J, Saveria T, Amos E, Duffy PE, Oleinikov AV – Structure-function-immunogenicity studies of PfEMP1 domain DBL2beta_PF11_0521, a malaria parasite ligand for ICAM-1. (2013) PLoS One, V. 8(4), p. e61323
  • Saveria T, Oleinikov AV, Williamson K, Chaturvedi R, Lograsso J, Keitany G, Fried M, Duffy PE – Antibodies to E.coli expressed C-terminal domains of Plasmodium falciparum VAR2CSA inhibit binding of CSA-adherent parasites to placental tissue. (2013) Infection & Immunity, V.81 (4), p. 1031-1039
  • Fried M, Avril M, Chaturvedi R, Fernandez P, Lograsso J, Narum D, Nielsen MA, Oleinikov AV, Salanti A, Saveria T, Williamson K, Dicko A, Scherf A, Smith JD, Theander TG, Duffy PE – Preclinical evaluation of pregnancy malaria vaccine immunogens: a multi-laboratory approach. (2013) Infection & Immunity, 81 (2), p. 487-495
  • Oleinikov AV, Voronkova V, Frey TI, Amos E, Morrison R, Fried M, Duffy PE – A survey of naturally acquired antibody responses to 38 PfEMP1 domains in plasma of Tanzanian infants reveals frequent recognition of VAR2CSA. (2012) PLoS One, V. 7, p.e31011
  • Oleinikov AV, Amos E, Frey TI, Rossnagle E, Mutabingwa TK, Fried M, Duffy PE – High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 P. falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodies. (2009) PLoS Pathogens, V. 5, p. e1000386
  • Oleinikov AV and Duffy PE. – Thoughts on placental malaria vaccine epitopes — pregnant but premature. Reply to Beeson et al. (2008) J. Infect. Diseases, V. 197, p. 1351-1352
  • Oleinikov AV, Francis SE, Dorfman JR , Rossnagle E, Balcaitis S, Getz T, Avril M, Gose S, Smith JD, Fried M, and Duffy PE – VAR2CSA domains expressed in E.coli induce cross-reactive antibodies to native protein. (2008) J. Infect. Diseases, V. 197, p. 1119-1123
  • Oleinikov AV and Gray MD – RNA Interference: The Next Gene Targeted Medicine. (2007) in book “Handbook of Pharmaceutical Biotechnology”, p. 1109 – 1148, ed. S.C. Gad, John Wiley & Sons, Inc., Hoboken, NJ

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Research Interest

  • Malaria studies with emphasis on mechanisms of sequestration of infected erythrocytes, protective immune response and vaccine development, anti-adhesion drugs.
  • High throughput and engineering approaches to advance studies of complex biological systems

Research Support

Past research support:

  • “Protective Immunity Against Severe Malaria in Young Children” (Consortium grant). Grand Challenges in Global Health/Bill and Melinda Gates Foundation
  • “Immunogens for a vaccine that will prevent pregnancy malaria globally” (Consortium grant). Bill and Melinda Gates Foundation
  • “Malaria at the Mother-child Interface” NIH 5D43TW005509
  • “High throughput screening for anti-adhesion drugs to treat severe malaria” NIH 1R56AI083668
  • “Pathways of Maternal Anemia” NIH 5R01HD058005
  • “Identification of vaccine candidates against severe malaria” NIH 1R01AI092120
  • “Mechanisms of Interaction between Malaria-infected Erythrocytes and Monocyte/Macrophages and Modulation of Innate Immune Activity” FAU Seed Grant

Memberships

  • American Society for Tropical Medicine and Hygiene 

Awards/Recognitions

  • FAU “Degree of Difference” Award for teaching graduate students, 2015
  • Faculty Research Mentoring Program award, 2015


Last Modified 1/6/17