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Charles E. Schmidt College of Medicine
Florida Atlantic University
777 Glades Road
Boca Raton, FL 33431

561-297-4828

Ning Quan, Ph.D.

Professor of Biomedical Science



The focus of my lab is on how the nervous system and immune system form a combined neuroimmune suprasystem. We are interested in understanding how these two systems communicate with each other to modulate each other’s function.  We use multiple techniques in molecular biology, neuroscience, and immunology to accomplish this goal.  This multi-disciplinary approach creates an ideal environment for training students on broad biomedical research subjects.  Advanced technologies such as FACS analysis, cloning, in-cell Western, patch-clamping electrophysiology, production of transgenic mouse and targeted transgenesis, and behavioral analysis are employed in my laboratory. Our current research led to the discovery of the euflammatory process, which can be used to design vaccine-based induction of immune responses as well as bacterial based cancer therapy.  We are also conducting detailed analysis on cell-type specific actions mediated by IL-1R1 using several lines of transgenic animals we created. This research has led to the identification of specific pathways related to the pathogenesis of various psychopathology caused by CNS inflammation.

 


  • 1985, Bioengineering, Huazhong Univ. of Science & Technology, China B.A
  • 1991, Physiology, University of Tennessee, Memphis, TN Ph.D
  • 1992, Neuroimmunology, Duke University Medical Center, Durham, NC Postdoctoral
  • 1998, Neuroimmunology, National Institute of Mental Health, MD Postdoctoral

 

  • 1987-1991 Graduate Research Assistant, Department of Physiology, University of Tennessee, Memphis, TN
  • 1991-1992 Postdoctoral Fellow, Department of Psychiatry, Duke University Medical Center, Durham, NC
  • 1992-1995 Instructor, Department of Psychiatry, Emory University School of Medicine, Atlanta, GA
  • 1995-1998 Intramural Training Fellow, National Institute of Mental Health, Bethesda, MD
  • 1998-2003 Assistant Professor, Oral Biology and Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH
  • 2003-2009 Associate Professor, Oral Biology and Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH
  • 2009-2019 Tenure Professor, Biosciences and Institute of Behavior Medicine, Ohio State University
  • 2009-2016 Chair, Oral Biology Graduate Program, Ohio State University
  • 2009-present Guest Professor, Sichuan University, China
  • 2017-present Guest Lead Scientist, Hamilton Biotechnology, Wuhan China
  • 2019-present Professor, Dept of Biomedical Science, Charles E. Schmidt College of Medicine and Investigator, Brain Institute, Florida Atlantic University, Boca Raton, FL

  • Bever, SR, Liu, X., Quan, N., and Pyter, LM. 2017. Euflammation attenuates central and peripheral inflammation and cognitive consequences of an immune challenge after tumor development. Neuroimmunomodulation 24: 74-86.

  • Anping Song, Ling Zhu, Gowthami Gorantla, Olimpia Berdysz, Stephanie A. Amici, Mireia Guerau-de-Arellano, Kathryn M. Madalena, Jessica K. Lerch, Xiaoyu Liu & Ning Quan. Salient type 1 interleukin-1 receptor expression

  • Xiaoyu Liu, Daniel P. Nemeth, Daniel B. McKim, Ling Zhu, Damon J. DiSabato, Olimpia Berdysz, Gowthami Gorantla, Braedan Oliver, Kristina G. Witcher, Yufen Wang, Christina E. Negray, Rekha S. Vegesna, John F. Sheridan, Jonathan P. Godbout, Matthew J. Robson, Randy D. Blakely, Phillip G. Popovich, Staci D. Bilbo and Ning Quan. Cell-type specific interleukin 1 receptor 1 signaling in the brain regulates distinct neuroimmune activities. Immunity 2019. 50:1-17.

  • Levi Todd, Isabella Palazzo, Lilianna Suarez, Xiaoyu Liu, Leo Volkov, Thanh V. Hoang, Warren A. Campbell, Seth Blackshaw, Ning Quan and Andy J. Fischer. Reactive microglia and IL1β/IL-1R1signaling mediate neuroprotection in excitotoxin-damaged mouse retina. Journal of Neuroinflammation 2019. 16:118.

  • Ling Zhu, Xiaoyu Liu, Daniel P. Nemeth, Damon J. DiSabato, Daniel B. Mckim, Braedan Oliver, Gowthami Gorantla, Olimpia Berdysz, Jiaoni Li, Aishwarya D. Ramani, and Ning Quan. Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling. Brain, Behavior, and Immunity (in press)

  • Damon DiSabato, Danny Nemeth, Xiaoyu Liu, Braedan Oliver, Jonathan Godbout, Ning Quan. Glutamatergic neuronal IL-1R1 is required for paired-fighting stress induced social withdrawal and working memory deficits. Molecular Psychiatry (in preparation).

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Active Funding

  • R01 MH109165    12/1/2015-12/1/2020    PI
    Anxiety, IL-1R1, and Neuroinflammation
    National Institute of Mental Health
  • R33 MH82118515    8/28/2018-8/28/2020    Co-I
    The role of the intestinal microbiome in anxiety and depression
  • R01 NS103785    12/15/2018-11/30/2023    Co-I
    Cell-Specific Actions of IL-1 / IL-1R1 Signaling Following Traumatic Brain Injury

Honors

  • 1998 Tanaguchi Young Investigator
  • 2001 Stazen Award for Junior Research Scientist
  • 2008 Stazen Award for Senior Research Scientist

Professional Societies

  • 2013-present Journal of Inflammation Research, Editor-in-Chief
  • 2017-2019 Regular study section member of PMDA
  • 2018-present Member, board of directors, PNIRS
  • 2004-2008 Regular study section member (NNB, neuro-endocrine, neuro-immunology, and behavior) of NIH review committee
  • 2010-2017 Ad hoc study section (PMDA) member of NIH review committee


Last Modified 9/23/19