Michele Pergadia, Ph.D. is an associate professor of Integrated Medical science and director of health behavior research. Her research informs health related behaviors, particularly smoking and associated factors such as depression. Her cross-disciplinary collaborations involve epidemiologic, genetic, human laboratory, and translational models to address these major public health problems. In addition to training and mentoring within that context, her track record as a principal investigator and co-investigator on National Institutes of Health and non-federal grants includes investigations of smoking and related behaviors. Her collaborative work is reflected in over 70 publications, including papers in JAMA Psychiatry, the American Journal of Psychiatry and Nature Genetics.
- 1987-1991: B.A., Biology and Psychology, Washington University, St. Louis, Missouri
- 1994-1998: M.S., Clinical Psychology, Finch University of Health Sciences/The Chicago Medical School, North Chicago, Illinois
- 1998-2001: Ph.D., Clinical Psychology, Finch University of Health Sciences/The Chicago Medical School, North Chicago, Illinois
- 2001: Health Psychology Resident, Rush Presbyterian St. Luke’s Medical Center, Chicago, Illinois
- 2001-2004: Postdoctoral Research Fellow/Associate, Genetic Epidemiology, Washington University School of Medicine, St. Louis, Missouri
- 2014-Present: Associate Professor of Integrated Medical Science and Director of Behavioral Health, College of Medicine, FAU
- 2014: Associate Professor of Psychiatry, Washington University School of Medicine, St. Louis, MO
- 2012-2014: Research Associate Professor of Psychiatry, Washington University School of Medicine, St. Louis, MO
- 2006-2012: Research Assistant Professor of Psychiatry, Washington University School of Medicine, St. Louis, MO
- 2004-2006: Research Instructor in Psychiatry, Washington University School of Medicine, St. Louis, MO
Representative Peer Review Publications
Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience,
18(2), 199-209. PMID: 25599223.
Pergadia, ML, Der-Avakian, A, D’Souza, M, Madden, PAF, Heath AC, Shiffman, S, Markou, A, Pizzagalli, DA (2014). Association between nicotine withdrawal and reward responsiveness in humans and rats. JAMA Psychiatry, 71 (11), 1238-1245. PMID: 25208057.
- Korhonen, T, Loukola, A, Wedenoja, J, Nyman, E, Latvala, A, Broms, U, Häppölä, A, Paunio, T, Perola, M, Schrage, A, Vink, J, Pergadia, ML, Madden, PAF, Kaprio, J (2014) Nicotine Dependence Potentiates the Association between the Dopamine Receptor Gene DRD3 and Major Depressive Disorder. PLoS One. Jun 13;9 (6):e98199. PMID: 24927283.
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet, 381 (9875), 1371-1379. PMID: 23453885.
Pergadia, ML & Gilbert, DG (2013). Commentary on Etter et al. (2013): The ups and downs of nicotine withdrawal and methods to study the process. Addiction, 108 (1), 60-61. PMID: 23279356.
- Wray, NR, Pergadia, ML, Blackwood, DHR, Penninx, BWJH, Gordon SD, Nyholt, DR, Ripke, S, MacIntyre, DJ, McGhee, KA, Maclean, AW, Smit, JH, Hottenga, JJ, Willemsen, G, Middeldorp, CM, de Geus, EJC, Lewis, CM, McGuffin, P, Hickie, IB, van den Oord, EJCG, Liu, J, Macgregor, S, McEvoy, BP, Byrne, EM, Medland, SE , Statham, DJ, Henders, AK, Heath, AC, Montgomery, GW, Martin, NG, Boomsma, DI, Madden, PAF, Sullivan, PF. (2012). Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Molecular Psychiatry, 17(1), 36-48. PMID: 21042317.
- Breen, G, Lewis, CM, Vassos, E, Pergadia, ML, Blackwood, DHR, Boomsma, DI, Penninx, B, Sullivan, PF, Pedroso, I., Collier, D, McGuffin, P. (2011). Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression. Nature Genetics, 43(1), 3-5. PMID: 21217634.
Pergadia, ML, Glowinski, AL, Wray, NR, Agrawal, A, Saccone, SF, Loukola, A, Broms, U, Korhonen,T, Penninx, BWJH, Grant, JD, Nelson, EC, Henders, AK, Schrage, AJ, Chou, Y, Kaisu, K, Zhu, R, Gordon, SD, Vink, JM, de Geus, EJ, MacGregor, S, Liu, JZ, Willemsen, G, Medland, SE, Boomsma, DI, Montgomery, GW, Rice, JP, Goate, AM, Heath, AC, Kaprio, J, Martin, NG, Madden, PAF. (2011). A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families. American Journal of Psychiatry, 168 (8), 848-852. PMID: 21572167.
Pergadia, ML, Agrawal, A, Heath, AC, Martin, NG, Bucholz, KK, & Madden, PAF (2010). Nicotine Withdrawal Symptoms in Adolescent and Adult Twins. Twin Research and Human Genetics, 13 (4), 359-69. PMID: 20707706.
- Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, Sulem P, Rafnar T, Esko T, Walter S, Gieger C, Rawal R, Mangino M, Prokopenko I, Mägi R, Keskitalo K, Gudjonsdottir IH, Gretarsdottir S, Stefansson H, Thompson JR, Aulchenko YS, Nelis M, Aben KK, den Heijer M, Dirksen A, Ashraf H, Soranzo N, Valdes AM, Steves C, Uitterlinden AG, Hofman A, Tönjes A, Kovacs P, Hottenga JJ, Willemsen G, Vogelzangs N, Döring A, Dahmen N, Nitz B, Pergadia ML, Saez B, De Diego V, Lezcano V, Garcia-Prats MD, Ripatti S, Perola M, Kettunen J, Hartikainen AL, Pouta A, Laitinen J, Isohanni M, Huei-Yi S, Allen M, Krestyaninova M, Hall AS, Jones GT, van Rij AM, Mueller T, Dieplinger B, Haltmayer M, Jonsson S, Matthiasson SE, Oskarsson H, Tyrfingsson T, Kiemeney LA, Mayordomo JI, Lindholt JS, Pedersen JH, Franklin WA, Wolf H, Montgomery GW, Heath AC, Martin NG, Madden PA, Giegling I, Rujescu D, Järvelin MR, Salomaa V, Stumvoll M, Spector TD, Wichmann HE, Metspalu A, Samani NJ, Penninx BW, Oostra BA, Boomsma DI, Tiemeier H, van Duijn CM, Kaprio J, Gulcher JR; ENGAGE Consortium, McCarthy MI, Peltonen L, Thorsteinsdottir U, Stefansson K. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics,
42(5):448-53. PMID: 20418888.
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- Director of Clinical and Translational Research Thread, M1-M4 curriculum
Editorial Board Member
- Scientific Reports
- Advances in Medicine
- American Psychological Association
- Society of Behavioral Medicine
- Society for Research on Nicotine and Tobacco
- Behavior Genetics Association
- Association of Psychologists in Academic Health Centers