Dr. Rajan Radhakrishnan is an Associate Professor of Integrated Medicine and Medical Educator (pharmacology) at the Charles E. Schmidt College of Medicine. He is a pharmacologist and a registered pharmacist in the states of Utah and West Virginia with more than 20 years of combined professional experience in industrial pharmacy, biomedical research, pharmacy practice, and academia as a teacher and as an administrator. Dr. Radhakrishnan’s research interests are: chronic pain mechanisms, statin-induced myalgia, TRPV and ASIC channels in ischemic- and inflammatory pain, TRPV and ASIC channels in prostatodynia and male chronic pelvic pain, cellular mechanisms of opioid tolerance and opioid-induced pain, Scholarship of Teaching and Learning (SoTL), muscarinic receptors in nociception and analgesia, hypertension, renin-angiotensin system and pain, common sites of central cardiovascular control and pain modulation, anti-addiction potential of herbal drugs, safety and efficacy assessment of natural products, drug interactions involving natural products, and toxicology.
Dr. Radhakrishnan has published 37 articles in international, peer-reviewed journals and 5 book chapters in his areas of expertise. He also serves as one of the editors of Phytotherapy Research (Wiley), Section Editor of Inflammopharmacology (Springer), Editorial Board Member of Journal of Pain (Elsevier), and a reviewer for more than 15 international scientific journals. He is a member of the American Association of Colleges of Pharmacy (AACP), American Pain Society (APS), and American Pharmacists Association (APhA). He also currently serves as a member of the Ethics Committee and Membership Committee of the American Pain Society.
- 1980: BSc., Chemistry, University of Kerala, India
- 1985: BS Pharm., University of Kerala, India
- 1988: MSc., Pharmacology, Strathclyde University, United Kingdom
- 1996: PhD., Pharmacology, National University of Singapore, Singapore
- 2005: Postdoctoral Fellowship, Pain Neurobiology, University of Iowa
- 2011: Academic Leadership Fellows Program, American Association of Colleges of Pharmacy
- 2017-Present: Associate Professor of Integrated Medical Science & Medical Educator, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida
- 2014-2017: Associate Dean for Academic Affairs, Professor of Pharmacy & McGee Chair, School of Pharmacy, University of Charleston, West Virginia
- 2012-2014: Assistant Dean for Academic Affairs & Assessment - Utah Campus, College of Pharmacy, Roseman University of Health Sciences (previously University of Southern Nevada)
- 2010-2011: Academic Leadership Fellows Program (ALFP) conducted by AACP – Dean Mentor: Mr. Ron P Jordan
2009-2012: Director of Academic Affairs & Assessment - Utah Campus, College of Pharmacy, University of Southern Nevada (currently Roseman University)
- 2010-2014: Professor of Pharmaceutical Sciences, College of Pharmacy, Roseman University of Health Sciences (previously University of Southern Nevada) – Utah Campus
2007-2015: Adjunct Associate Professor of Anesthesiology, Department of Anesthesiology, University of Utah Medical School, Salt Lake City
- 2007-2010: Associate Professor of Pharmaceutical Sciences, College of Pharmacy, University of Southern Nevada (currently Roseman University) – Utah Campus
2005-2007: Assistant Professor of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California
- 2004-2005: Research Investigator, Neurophysiology of Pain Laboratory, Department of Physical Therapy, University of Iowa Medical School, Iowa City, Iowa
2002-2004: Research Fellow, Neurophysiology of Pain Laboratory, Department of Physical Therapy, University of Iowa Medical School, Iowa City, Iowa
- 1996-2001: Pharmacologist, Department of Pharmacology & Toxicology, Zayed Complex for Herbal Research & Traditional Medicine, Ministry of Health, United Arab Emirates
1995-1996: Lecturer (equivalent to Assistant Professor in the US), Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
- 1986-1991: Industrial Pharmacist, Kerala State Drugs & Pharmaceuticals Ltd., & Kerala State Homeopathic Co-operative Pharmacy Ltd., Alleppey, Kerala, India
Jan 1986-Oct 1986: Trainee Industrial Pharmacist, Kerala State Drugs & Pharmaceuticals Ltd., India
- Izzo AA, Hoon-Kim S, Radhakrishnan R, Williamson EM. A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies. Phytother Res. 2016, 30:691-700.
- Unni E, Mandal M, Radhakrishnan R, Johanson E, Stolte S, Jorvig E. Knowledge Retention of Basic Pharmaceutical Sciences in a PharmD program. Currents in Pharmacy Teaching and Learning. 2016, 8(6): 827-832.
- Pfeiffenberger JA, Rhoney DH, Cutler SJ, Oliveira MA, Whalen KL, Radhakrishnan R, Jordan RP. Examining Perceptions of Tenure and Tenure Reform in Academic Pharmacy. Am J Pharm Educ. 2014, 78(4): Article 75.
Radhakrishnan R, Santamaría A, Escobar L, Arias HR. The β4 nicotinic receptor subunit modulates the chronic antidepressant effect mediated by bupropion. Neurosci Lett. 2013, 555:68-72.
- Kullgren J, Radhakrishnan R, Unni E, Hanson E. An integrated course in pain management and palliative care, bridging the basic sciences and pharmacy practice. Am J Pharm Educ 2013, 77(6):121.
Zhang J, Kullgren J, Radhakrishnan R. Cancer pain management. America’s Pharmacist. Feb 2013.
- Walder RY, Radhakrishnan R, Loo L, Rasmussen LA, Mohapatra DP, Wilson SP, Sluka KA. TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain. 2012, 153:1664-72.
- Unni E, Zhang J, Radhakrishnan R, Smith K, Bridgen CM, Deyoung M, Metzger T. Predictors of academic performance of pharmacy students based on admission criteria in a 3-year pharmacy program. Currents in Pharmacy Teaching and Learning. 2011, 3:192-198.
Radhakrishnan R, Sluka KA, Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain, Neurosci. Lett. 2009, 457:141-145.
Radhakrishnan R, Nallu S. Development and characterisation of a novel animal model of prostate inflammation-induced chronic pelvic pain. Inflammopharmacology.2008 Dec 26.[Epub ahead of print]. 2009, 17:23-28.
- Sluka KA, Radhakrishnan R, Benson CJ, Eshcol JO, Price MP, Babinski, K, Audette KM, Yeomans DC, Wilson SP. ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain. 2007, 129:102-112.
- Vance, CGT, Radhakrishnan, R, Skyba, DA., Sluka, KA. Both high and low frequency TENS reduce primary hyperalgesia in rats with joint inflammation in a time-dependent manner. Phys Ther, 2007, 87:44-51.
- Sluka KA, Skyba DA, Radhakrishnan R, Leeper BJ, Wright A.Joint mobilization reduces hyperalgesia associated with chronic muscle and joint inflammation in rats. J Pain. 2006, 7:602-607.
- Ainsworth L, Budelier K, Clinesmith M, Fiedler A, Landstrom R, Leeper BJ, Moeller L, Mutch S, O’Dell K, Ross J, Radhakrishnan R, and Sluka KA. Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation. Pain. 2006, 120:182-187.
Radhakrishnan R, Sluka KA. Deep tissue afferents, but not cutaneous afferents, mediate TENS-induced antihyperalgesia. J Pain. 2005, 6:673-680.
Radhakrishnan R, Sluka KA. Acetazolamide, a carbonic anhydrase inhibitor, reverses inflammation-induced thermal hyperalgesia in rats. J Pharmacol Exp Ther. 2005, 313:921-927.
- Skyba DA., Radhakrishnan R, and Sluka KA. A method to measure primary hyperalgesia directly from the muscle of rats. J. Pain. 2005, 6:41-47.
- Skyba DA, Radhakrishnan R, Hoeger Bement MK, Sluka KA. The cAMP pathway and pain: Potential targets for drug development. Drug Discovery Today: Disease Models. 2004, 1:115-119.
- Chen HB, Islam MW, Radhakrishnan R, Wahab SA, Naji MA. Influence of aqueous extract from Neurada procumbens L. on blood pressure of rats. J Ethnopharmacol. 2004, 90:191-194.
Radhakrishnan R, Sluka KA. Spinal muscarinic receptors are activated during low or high frequency TENS-induced antihyperalgesia in rats.Neuropharmacology. 2003, 45:1111-1119.
- Skyba DA, Radhakrishnan R, Rohlwing JJ, Wright A and Sluka KA. Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord. Pain, 2003, 106:159-168.
Radhakrishnan R, King EW, Dickman J, Richtsmeier C, Schardt N, Spurgin M, Sluka KA. 5-HT2 and 5-HT3 receptors mediate low, but not high, frequency TENS- induced antihyperalgesia in rats. Pain, 2003,105:205-213.
Radhakrishnan R, Moore SA, Sluka KA. Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats. Pain, 2003, 104:567-577.
- Hoeger Bement MK, Skyba DA, Radhakrishnan R, Sluka KA. Musculoskeletal Pain: Central mechanisms. Semin Pain Med. 2003, 1: 139-149.
- Zakaria MNM, Islam MW, Radhakrishnan R, Liu XM, Ismail A, Kamil M, Chan K, Al-Attas A. Evaluation of anti-gastric ulcer and cytoprotective properties of Caralluma arabica. Pharmaceutical Biol., 2002, 40: 225-230.
- Islam MW, Zakaria MNM, Radhakrishnan R, Kamil M, Chan KC, And Al-Attas A. Effect of Teucrium stocksianum on gastric ulceration and secretion in rats. Pharmaceutical Biol., 2002, 40: 216-220.
Radhakrishnan R, Zakaria MNM, Islam MW, Kamil M, Ismail A, Chan K, Al-Attas A. Analgesic and anti-Inflammatory activities of Teucrium stocksianum (Boiss) Pharmaceutical Biol. 2001, 39: 455-459.
- Liu. X.M, Zakaria MNM, Islam MW, Radhakrishnan R, Ismail A, Chen HB, Chan K, Al-Attas A. Anti-Inflammatory and anti-gastric ulcer activity of Calligonum comosum L, Hert. in rats. Fitoterapia, 2001, 72: 487-491.
Radhakrishnan R, Zakaria MNM, Islam MW, Chen HB, Kamil M, Chan K and Al-Attas A. Neuropharmacological actions of Portulaca oleraceaeL. v. sativa (Hawk).J Ethnopharmacol. 2001, 76: 171-176.
- Zakaria, MNM, Islam MW, Radhakrishnan R, Chen HB, Kamil M, Al-Gifri AN, Chan K, Al-Attas A. Analgesic and anti-Inflammatory properties of Caralluma Arabica. J. Ethnopharmacol. 2001, 76: 155-158.
- Chan K, Islam MW, Kamil M, Radhakrishnan R, Zakaria MN, Habibullah M, Attas A. The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. Sativa (Haw.) celak. J Ethnopharmacol. 2000, 73: 445-451.
Radhakrishnan R, Sim M.K. Actions of d-amino acid-substituted analogues of des-Asp-angiotensin I on the central pressor action of angiotensin III. Eur J Pharmacol. 1995, 294: 337-339.
Radhakrishnan R, Sim MK. Enhanced Pressor Response to Angiotensin III in Spontaneously Hypertensive Rats: Effects of Losartan. Eur J Pharmacol, 1994, 259: 87-90.
- Sim MK, Radhakrishnan R. In vivo Study of Angiotensin II Tachyphylaxis in Freely Moving Normo- and Hypertensive Rats. Pharmacol Toxicol, 1994, 74: 223-227.
- Sim MK, Radhakrishnan R. Novel Central Actions of des- Asp- angiotensin I. Eur JPharmacol 1994, 257: R1-R3.
- Sim MK, Radhakrishnan R. Effect of Pentobarbital and Chlordiazepoxide on the Central Pressor Effects of Angiotensins in Normo- and Hypertensive Rats.,Eur J Pharmacol, 1994, 253: 171-174.
Radhakrishnan R, Wadsworth, RM, Gray AI. Terminalia arjuna, an Ayurvedic Cardiotonic, Increases Contractile Force of Rat Isolated Atria. Phytotherap Res, 1993, 7: 266-268.
Radhakrishnan R. Revised and prepared review questions for Chapters 3, 4, 5, 6 and 7 on “The Autonomic System”, “Cholinergic Agonists”, “Cholinergic Antagonists”, “Adrenergic Agonists” and “Adrenergic Antagonists” respectively, for Lippincott’s Illustrated Review of Pharmacology 6e.
- Shankar GS, Radhakrishnan R. 2011. History of Antipsychotic Drug Development. In Development of Therapeutic Agents Handbook. (SC Gad ed.). John Wiley.
- Sluka, KA., Hoeger-Bement, M., Audette, K., Skyba, D., Radhakrishnan R, 2007. Second messenger pathways in pain. In Molecular Pain (Zhuo M.ed.). pp 219-234. Springer-Higher Education Press.Radhakrishnan R., Bement M., Skyba D., Kehl L., Sluka KA. 2004. Models of muscle pain: Carrageenan model and acidic saline model. In Current Protocols in Pharmacology (Enna S.J., Williams M., Ferkany J., Kenakin T., Porsolt R., and Sullivan J., eds.) pp. 5.35.1-5.35.28. John Wiley & Sons, Hoboken, N.J.
- Sluka KA, Radhakrishnan R, Price MP, Welsh MJ. 2004. ASIC3 mediates mechanical hyperalgesia induced by muscle injury. In Hyperalgesia: Molecular Mechanisms and Clinical Implications (Brune K and Handwerker HO., eds.) pp 105-111. IASP Press, Seattle.
- Registered Pharmacist, State of West Virginia, USA., February 2016-present.
- Registered Pharmacist, State of Utah, USA., 2015 Oct –present
- Registered Pharmacist, Pharmacy Council of Kerala, India, 1985-present.
Memberships & Affiliations
- Member, American Pain Society, USA, 2002-present.
- Member, Society for Neuroscience, USA, since 2002-2014.
- Member, American Association of Colleges of Pharmacy (AACP), 2005-present.
- Member, American Society of Anesthesiologists, 2012-13.
- Member, American Society of Pharmacology and Experimental Therapeutics, 2005-2007.
- Member, Institute of Biology, London, UK, 1996-2006.
- Member, Singapore Neuroscience Society, Singapore, 1992-1995.
- Member, Society for Medicinal Plants Research, Germany, 1993-2004.
- Member, Biomedical Research & Experimental Therapeutics Society of Singapore, 1992-1995.
- Editor- Phytotherapy Research (Wiley InterScience, since 2011)
- Section Editor-Inflammopharmacology (Sringer, since 2004)
- Editorial Board Member - Journal of Pain (American Pain Society, since 2010)
- Editorial Board Member- Phytomedicine (Elsevier, 2003-2011)
Honors & Awards
- Invited as a member of the WHO Working Group on a document on ‘Clinical Research in Traditional Medicine’, Macau, October 2015.
- Appointed as the McGee Chair, University of Charleston School of Pharmacy, 2014.
- Appeared in the ‘APS Member Spotlight’ of American Pain Society, May 2012 (http://www.americanpainsociety.org/membership/Member-Spotlight/rajanradhakrishnan.html)
- Nominated to Scientific Programming Committee of American Pain Society, 2011 and 2012.
- Nominated to Ethics Committee of American Pain Society, 2010.
- APS Travel Grant to attend 26th Annual Scientific Meeting of the American Pain Society, 2007, Washington DC, USA.
- APS Travel Grant to attend 25th Annual Scientific Meeting of the American Pain Society, 2006, San Antonio, Texas, USA.
- American Pain Society Scholarship to attend a course on “Essentials of Pain Management: Principles and Practice”, and 24th Annual Scientific Meeting of the American Pain Society, 2005, in Boston, USA.
- Arthritis Foundation Travel Award, Arthritis Research Conference, Keystone, Colorado, June 2003.
- Pfizer Young Investigator Travel Grant, American Pain Society Meeting, Chicago, 2003 March.
- Nominated to the “National Committee for Regulating the Use of Pesticides in UAE” by the Ministry of Health, United Arab Emirates, in 1997.
- Young Scientist Award, Biomedical Research & Experimental Therapeutics Society of Singapore, in 1993.
- NUS Scholarship by the National University of Singapore for pursuing a PhD program in pharmacology at NUS, in 1991.
- Shared Scholarship from the Overseas Development Administration of Great Britain and the University of Strathclyde for pursuing a masters program in pharmacology at Strathclyde, in 1988.
- Bottlenecks in Innovative and Translational Research in Traditional Medicine. 2015 Innovative TCM and Botanic Drug International Summit, Zhangjiakou, PR China.
Plenary Lecture: Major Reasons for Rejection of Manuscripts on Natural Products. Indian Pharmaceutical Congress, Hyderabad, India, January 2015.
- Academic Affairs Administration: My Vision & Philosophy. University of Charleston School of Pharmacy, Charleston, WV, March 2014.
- NSAIDs: An Overview for Medical Residents. University of Utah Pain Center, April 2013.
- Neuropathic Pain: Pathophysiology & Pharmacology. School of Medicine & School of Pharmacy. Amrita Institute of Medical Sciences, Kochi, India, December 2011.
Plenary Lecture: Innovations in Pharmacy (PharmD) Education in the US. Indian Pharmaceutical Congress, Bangalore, India, December 2011.
- ‘An overview of the PharmD programs in the USA’. College of Pharmacy, Amrita Institute of Medical Sciences, Kochi, India, August 2010.
- Development and characterization of animal models of intermittent claudication, and prostatitis-induced pelvic pain. Pain Research program &Department of Pharmacology, University of Iowa, Iowa City, USA, June 2009.
- “Bug Busters”. A simplified lecture on antimicrobials given to Grade 6 Accelerated Learning Program Students, Jordan Ridge Elementary School, South Jordan, Utah, USA, May 2009.
- Basic Pain Neurobiology & Pharmacology. CE Program for Pharmacists in Pain Management (Instructor), University of Southern Nevada, Utah Campus, USA, March2009
- Involvement of ASIC and P2X Channels in Ischemic Pain. Slide Presentation, Society for Neuroscience Meeting, Washington DC, Nov 2008.
- Development and characterization of an animal model of chronic pelvic pain due to prostate inflammation.9th International Conference on Inflammopharmacology, Queens’ College, University of Cambridge, UK, Sept 2008.
- The Role of TRPV1 Ion Channels in a Novel Model of Ischemic Muscle Pain. AACP Annual Meeting, Chicago, July 2008.
- Involvement of ion channels in ischemic pain transduction. Data Blitz, American Pain Society Meeting, Tampa, FL, May 2008.
- Injury, pH and Pain- Part II. Pain Research Center, University of Utah, Salt Lake City, UT, March 2008.
- Injury, pH and Pain- Part I. Pain Research Center. University of Utah, Salt lake City, Utah, USA. December 2007.
- M1 and M3 muscarinic antagonists reverse TENS-induced antihyperalgesia. Arthritis Research Conference organized by Arthritis Foundation, Keystone, Colorado, USA, June 2003.
- Morphine-induced abnormal pain. Pain Research Program Journal Club, University of Iowa, USA, April 2003.
- Deep tissue afferents or cutaneous afferents? Involvement in TENS-induced antihyperalgesia. Pain Research Program, University of Iowa, USA, March 2003.
- India – A country of cultural diversity. North Liberty Boy’s Scouts Meet. Scheffer Hall, University of Iowa, USA, March 2003.
- Angiotensin and Nociception. Pain Research Program, University of Iowa, USA., May 2002.
- Involvement of 5-HT receptor subtypes in TENS- induced anti-hyperalgesia. Regional Pain Interest Group Meeting, Medical College of Wisconsin, Milwaukee, USA, June 2002.
- Involvement of angiotensin peptides in hypertension – a better perception. Faculty of Pharmacy, Kuwait University, Kuwait, May 2001.
- Pharmacological activities of Portulaca olearaceae. Zayed Complex for Herbal Research & Traditional Medicine, United Arab Emirates, September 1997.
- Effects of GABA-ergic drugs on pressor responses to centrally administered angiotensins. Department of Pharmacology, National University of Singapore, January 1995.