College of Medicine / About / Departments / Biomedical Science Department / Massimo Caputi, Ph.D.


       

Charles E. Schmidt College of Medicine
Florida Atlantic University
777 Glades Road
Boca Raton, FL 33431

561-297-4828

MASSIMO CAPUTI, Ph.D.

Associate Professor of Biomedical Science


caputi
CONTACT
mcaputi@health.fau.edu
Tel. (561) 297-0627

 
 

Massimo Caputi, PhD., is an associate professor of biomedical science. His research interests include: mRNA processing, mRNA splicing regulation, HIV-1 replication and Bcl apoptotic gene family regulation.The Caputi lab studies the mechanisms that regulate mRNA processing and gene expression in viral and cellular substrates. Cancer and genetic disease are often caused by the breakdown of these complex mechanisms. A clear understanding of messenger RNA biogenesis will be an invaluable help in our quest for fighting human disease. The mechanisms that regulate the life of a messenger RNA from transcription to splicing, polyadenylation, export and degradation are tightly connected in a complex web of interactions. Our lab focuses on the interaction between the cellular Transcription - RNA processing - Translation machinery and cellular and viral genes that are the cause of human disease. HIV-1 and oncogenes are the primary targets of our research.

 


  • 1996: Ph.D., Molecular Genetics, International School for Advanced Studies, Trieste, Italy
  • 1992: Degree in Biological Science (magna cum laude), University of Trieste, Italy

  • 2010-Present: Associate Professor, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL
  • 2005-Present: Adjunct Assistant Professor, Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL
  • 2007-2010: Associate Professor, College of Biomedical Science, Florida Atlantic University, Boca Raton, FL
  • 2004-2011: Adjunct Assistant Professor, Microbiology Department, University of Miami School of Medicine, Miami, FL
  • 2003-2007: Assistant Professor, College of Biomedical Science, Florida Atlantic University, Boca Raton, FL
  • 2001-2003: Associate Research Scientist, Johns Hopkins University, Baltimore, Maryland
  • 1996-2001: Postdoctoral Fellow, Center for Molecular Biology of RNA, University of Santa Cruz, CA

  • Paz, S., Lu, M.L., Takata, H., Trautmann, L., Caputi, M. (2015). SRSF1 RNA recognition motifs are strong inhibitors of HIV-1 replication. J Virol, 89(12), 6275-6286.
  • Sean Paz, Adrian R. Krainer and Massimo Caputi . (2014) HIV-1 transcription is regulated by splicing factor SRSF1. Nucleic Acids Res. 42:13812-13823
  • Jacques Jean-Philippe,Sean Paz, Michael L. Lu and Massimo Caputi . (2014) A truncated hnRNP A1 isoform, lacking the RGG-box RNA binding domain, can efficiently regulate HIV-1 splicing and replication. BBA-Gene Regul. Mech. 1839(4):251-8Massimo Caputi (2011) The regulation of HIV-1 mRNA biogenesis. RNA Processing .  InTech. 79-100.
  • Joseph A. Jablonski, Antonio A. Amelio, Mauro Giaccaand Massimo Caputi. (2010)The transcriptional transactivator Tat regulates viral splicing. Nucleic Acids Res.38(4), 1249-60
  • Martina Huranová, Joseph A. Jablonski, Aleš Benda, Martin Hof, David Staněkand Massimo Caputi (2009) In vivo detection of RNA-binding protein interactions with cognate RNA sequences by fluorescence resonance energy transfer. RNA. 15, 2063-71.
  • Antonio A. Amelio, Massimo Caputi, and Michael D. Conkright(2009) Bipartite Functions of the CREB Coactivators Selectively Direct Alternative Splicing or Transcriptional Activation. EMBO J.28, 2733-47.
  • Joseph A. Jablonski and Massimo Caputi. (2009). Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity. J. Virology83, 981-992.
  • Joseph A. Jablonski, Emanuele Buratti, Cristiana Stuani and Massimo Caputi. (2008) The secondary structure of the HIV-1 transcript modulates viral splicing and infectivity. J. Virology. 82, 8038-50.
  • Michael Schaub, Suzette L. Lopez and Massimo Caputi. (2007) Members of the heterogeneous nuclear ribonucleoprotein (hnRNP) H family activate splicing of an HIV-1 splicing substrate by promoting formation of ATP-dependent spliceosomal complexes.. J. Biol. Chem.282, 13617-26.
  • Jeremy E. Wilusz, Sean C. Devanney and Massimo Caputi.. (2005) Chimeric peptide nucleic acid compounds modulate splicing of the bcl-x gene in vitro and in vivo. Nucleic Acids res.33(20): 6547-54.
  • Alan M. Zahler, Christian K. Damgaard, Jorge Kjems and Massimo Caputi. (2004). SC35 and hnRNPs A/B binding to a juxtaposed ESE/ESS element regulates HIV-1 tat exon 2 splicing. J. Biol. Chem., 279, 10077-10084.

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Research Interests

The Caputi lab studies the mechanisms that regulate mRNA processing and gene expression in viral and cellular substrates. Cancer and genetic disease are often caused by the breakdown of these complex mechanisms. A clear understanding of messenger RNA biogenesis will be an invaluable help in our quest for fighting human disease. The mechanisms that regulate the life of a messenger RNA from transcription to splicing, polyadenylation, export and degradation are tightly connected in a complex web of interactions. Our lab focuses on the interaction between the cellular Transcription - RNA processing - Translation machinery and cellular and viral genes that are the cause of human disease. HIV-1 and oncogenes are the primary targets of our research.



Last Modified 12/15/16