Charles E. Schmidt College of Medicine
Florida Atlantic University
777 Glades Road
Boca Raton, FL 33431

561-297-4828

MAHYAR NOURI-SHIRAZI, D.V.M., Ph.D.

Professor of Integrated Medical Science

CONTACT
mnourish@health.fau.edu
Tel. (561) 297-0935

Mahyar Nouri-Shirazi, D.V.M., Ph.D., is a Professor in the Department of Integrated Medical Science at the Charles E. Schmidt College of Medicine at Florida Atlantic University. Dr. Nouri-Shirazi is an immunologist with an interest in basic immunology, specifically the application of its principles to clinical settings. Research in his laboratory is focused on 1) dendritic cells (DCs)-based immunomodulation for treatment of cancer and allograft rejection and 2) TLR agonists as adjuvants to augment vaccine efficacy in immunocompromised individuals. Among his responsibilities, he teaches Immunology to M1 and M2 medical and graduate students, facilitates small group cases, and serves as director of the M2 Pathophysiology and Therapeutics 4 course.

1992: D.V.M., Tottori University, School of Veterinary Medicine, Japan
1996: Ph.D., Immunology, Chiba University, School of Medicine, Japan

2017-Present: Professor & Director of Flow Cytometry Core Facility, Florida Atlantic University, Charles E. Schmidt College of Medicine, Boca Raton, FL.
2011-2017: Associate Professor & Director of Flow Cytometry Core Facility, Florida Atlantic University, Charles E. Schmidt College of Medicine, Boca Raton, FL.
2008-2011: Assistant Professor & Director of Flow Cytometry Core Facility, Florida Atlantic University, Charles E. Schmidt College of Medicine, Boca Raton, FL.
2001-2008: Assistant Professor, Texas A&M University Health Science Center-BCD, Dallas, TX.
2005-2008: Adjunct Assistant Professor, Baylor University, Waco, TX.
1998-2001: Senior Postdoctoral Fellow, Baylor Institute for Immunology Research, Dallas, TX.
1996-1998: Research Scientist, Bayer Pharmaceutical Ltd, Research Center Kyoto, Kyoto, Japan.
1994-1996: Research Scientist, Columbia University, Department of Microbiology, New York, NY.

M. Nouri-Shirazi, C. Kahlden, P. Nishino, and E. Guinet. Nicotine Exposure Alters the mRNA Expression of Notch Ligands in Dendritic Cells and Their Response to Th1-/Th2-Promoting Stimuli. Scandinavian Journal of Immunology Volume 81, Issue 2, Pages 110-120, February 2015.
M. Nouri-Shirazi and E. Guinet. Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination. The Journal of ImmunologyVolume 188, Number 5, Pages: 2359-70 MAR 2012.
M. Zeng, E. Guinet and M. Nouri-Shirazi. B7-1 and B7-2 differentially control peripheral homeostasis of CD4+CD25+Foxp3+ regulatory T cells. B7-1 and B7-2 differentially control peripheral homeostasis of CD4+CD25+Foxp3+ regulatory T cells. Transplant Immunology 20 (3): 171-179 JAN 2009
M. Nouri-Shirazi, AW. Thomson. Dendritic cells as promoters of transplant tolerance. Expert Opinion On Biological Therapy 6 (4): 325-339 APR 2006
M. Nouri-Shirazi, E. Guinet. A possible mechanism linking cigarette smoke to higher incidence of respiratory infection and asthma. Immunology Letters 103 (2): 167-176 MAR 15 2006
M. Nouri-Shirazi, E. Guinet. Evidence for the immunosuppressive role of nicotine on human dendritic cell functions. Immunology 109 (3): 365-373 JUL 2003
M. Nouri-Shirazi, E. Guinet. Direct-, and Indirect Cross-Tolerance of Alloreactive T cells by Dendritic cells Retained in the Immature Stage. Transplantation 74 (7): 1035-1044 OCT 15 2002
F. Berard, P. Blanco, J. Davoust, E.M. Neidhart-Berard, M. Nouri-Shirazi, N. Taquet, D. Rimoldi, J.C. Cerot-tini, J. Banchereau, and A. K. Palucka. Cross-priming of naïve CD8+ T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. Journal of Experimental Medicine 192 (11): 1535-1543 DEC 4 2000
M. Nouri-Shirazi, J. Banchereau, D. Bell, S. Burkeholder, E. T. Kraus, J. Davoust, and Karolina A. Palucka. Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. The Journal of Immunology 165 (7): 3797-3803 OCT 1 2000
Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RS, Rothman P, Stall AM, Pandolfi PP, Dalla-Favera R. The BCL-6 proto-oncogene controls germinal-centre formation and Th-2-type inflammation. Nature Genetics 16 (2): 161-170 JUN 1997

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Honors and Awards

2007 Basic Science Faculty Research award, Texas A&M University Health Science Center

2011 Teaching and presentation Award, American Association for Laboratory Animal Science

2011 Dwight W. Warren Award for Excellence in Graduate Teaching, FAU-CESCOM

2012 Researcher Excellence Award, American Association for Laboratory Animal Science

2012 Laboratory Travel Award, American Association of Immunologists

2014 Outstanding Problem-Based Learning (PBL) Facilitator Award, FAU-CESCOM

2014 Laboratory Travel Award, American Association of Immunologists

2015 Laboratory Travel Award, American Association of Immunologists

Research funding

Principal Investigator: NIH-NIAID 1R03AI103750-01A1

Principal Investigator: Georgia Aquarium180288

Principal Investigator: Phillip Morris Inc,. USA

Mentor: Natural Science Foundation of China (NSFC)

Mentor: NIH-NIDCR K23 DE00-469-01

Collaborator: NIH-NINDS 1R15NS066339

Co-investigator: CaPCURE

Senior Postdoctoral Fellow: NIH-NIAID R01CA78846-01A1

Patent

Inventor: US file patent number 60/159,903

Inventor: US file patent number US10/110,553

Inventor: US Provisional patent #61/596,919

Editorial and Professional Affiliations

Member: American Association of Immunologists (AAI)

Member: American Association of Cancer Research (AACR)

Member: American Society of Transplantation (AST)

Editorial Board: Annals of Vaccines and Immunization