Charles E. Schmidt College of Medicine
Florida Atlantic University
777 Glades Road, BC-71
Boca Raton, FL 33431
Research in Dr. Wen Shen’s laboratory has focused on cellular and molecular mechanisms underlying synaptic function and neuroplasticity in brain and sensory system. Using in vivo animal models and in vitro retinal tissues and human brain tissues, Dr. Shen’s lab addresses the fundamental questions regarding how individual cells and complex of neural circuits interact at processing of information in these systems; and what the roles of membrane receptors, transporters, ion channels and intracellular pathways play in signal transduction and modulation in health and diseased brain and retina. Dr. Shen’s lab is also interested in development of non-invasive treatment strategies aimed at mitigating or preventing retinal degeneration and loss of visual function. The research emphasis is on the study of the neuroprotective mechanisms of neurotrophic factors and neuroprotective agents in against of retinal degeneration as a consequence of photoreceptor loss in retinal diseases. The study can provide insight into developing effective therapeutic drug(s) for prevention and treatment of neural dysfunction in the early stages of neuronal degenerative diseases. Multifaceted experimental approaches are used in Dr. Shen’s laboratory, including genetic engineering, electrophysiological recording and optical imaging techniques. Over the years, Dr. Shen’s research has been supported by National Institute of Health, National Science Foundation and Fight for Sight, Prevent Blindness America.